Short-term mortality risks among patients with non-metastatic bladder cancer
- PDF / 916,311 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 97 Downloads / 153 Views
RESEARCH ARTICLE
Open Access
Short-term mortality risks among patients with non-metastatic bladder cancer Menghe Zhai†, Chenye Tang†, Ming Li, Xin Chen, Yigang Jin, Xiangjun Ying, Zhiling Tang, Xiao Wang, Yuntao Wu, Chun Sun, Kean Chen and Xiao Guo*
Abstract Background: Population-based analysis for the short-term non-bladder cancer related mortality among patients with non-metastatic bladder cancer is currently lacking. The objective of the current study was to assess and quantify cause of death after bladder cancer diagnosis. Methods: The custom Surveillance, Epidemiology, and End Results (SEER) dataset for standardized mortality ratios (SMRs) was utilized to identify 24,074 patients who were diagnosed with nonmetastatic (M0) bladder cancer from 2014 to 2015. SMRs for causes of death were calculated. Risk factors for bladder cancer-specific mortality, competing mortality, second-cancer mortality, and noncancer mortality were determined using either multivariable Cox or competing risk regression models. Results: Among all the 4179 (17.4%) deaths occurred during the follow-up period, almost half of them (44.2%) were attributed to non-bladder cancer cause, including second non-bladder cancer (10%) and other non-cancer causes (34.2%). The most common noncancer causes of death were heart diseases followed by chronic obstructive pulmonary disease. Patients had a higher risk of death from second malignancies (SMR, 1.59; 95% CI, 1.47–1.74) compared with death from first malignancies in the US general population, and also had higher risks of death from heart diseases (SMR, 1.29; 95% CI, 1.18–1.40) and chronic obstructive pulmonary disease (SMR, 1.52; 95% CI, 1.29– 1.79) compared with the US general population. Additionally, some risk factors for competing second malignancies or noncancer mortality were determined, such as age, gender, marital status and treatment modalities. Conclusions: Death from non-bladder cancer cause contributed to almost half of all deaths in bladder cancer survivors during the short-term follow-up period. These findings can inform medical management and assist clinicians in counseling those survivors regarding their short-term health risks. Keywords: Bladder cancer, Causes of death, Survivorship, Short-term survival, SEER
Background Bladder cancer is the sixth most common cancer and the second commonly diagnosed genitourinary malignancy [1], accounting for approximately 4.6% of all newly diagnosed cancer and for approximately 2.8% of cancer directed deaths in the United States. According * Correspondence: [email protected] † Menghe Zhai and Chenye Tang contributed equally to this work. Department of Urology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang Province, People’s Republic of China
to the latest cancer statistic report, an estimated 81,190 new cases of bladder carcinoma were expected to be diagnosed in 2018 in the United States nationally, with 17, 240 deaths caused by this disease [2]. Increasing age is considered as the main risk factor for bladder ca
Data Loading...
