Silent and dangerous: catheter-associated right atrial thrombus (CRAT) in children on chronic haemodialysis
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ORIGINAL ARTICLE
Silent and dangerous: catheter-associated right atrial thrombus (CRAT) in children on chronic haemodialysis Martin Garcia-Nicoletti 1 & Manish D. Sinha 1,2 Francis Calder 1,6
&
Alexandra Savis 3 & Shazia Adalat 1 & Narayan Karunanithy 4,5 &
Received: 6 April 2020 / Revised: 5 July 2020 / Accepted: 24 August 2020 # The Author(s) 2020
Abstract Background Catheter-associated right atrial thrombus (CRAT) is a recognised complication of central venous catheter (CVC) use for haemodialysis (HD) patients. Methods This was a single-centre retrospective longitudinal observational study of consecutive children aged 6 months–18 years over a 7-year period receiving in-centre chronic HD. Echocardiograms as per routine cardiac surveillance were performed 6 months or earlier given clinical concerns. Results Sixty-five children, 36 boys (55.4%), median (IQR) age 11.8 (5.3, 14.7) years, received HD for kidney failure with replacement therapy (KFRT). Initial modality was HD in 45 (69.2%), with CVC as initial access in 42 (93.3%) and AVF in 3 (6.7%); in the remaining 20 (30.8%) patients PD was the initial modality before switching to HD. Seven of 65 (10.8%) developed CRAT at median 2 (0.8, 8.4) months from CVC insertion, with one CRAT detected 3 days following insertion. One child had 2 episodes of CRAT and one additionally thrombosed their AVF. No patient had an underlying primary kidney disease associated with a pro-thrombotic state. Those with CRAT were younger, had more frequent CVC change and received dialysis for longer duration compared to those with no CRAT. Six episodes of CRAT (75%) received anticoagulation therapy. Infective complications were observed in 25% and catheter malfunction in 50%. Five CRAT episodes (62.5%) resulted in CVC loss. One patient died after a haemorrhagic complication of anticoagulation and sepsis, and another developed life-threatening superior vena cava obstruction syndrome. Overall mortality 14% (1/7). Conclusions This is the first report of CRAT in a paediatric HD population. There was ~ 11% incidence of CRAT in patients receiving chronic HD detected by surveillance echocardiography. Although frequently asymptomatic, CRAT is associated with serious sequelae. Anticoagulation and surveillance with expert echocardiography remain mainstays of management.
Keywords CRAT . Catheter-associated right atrial thrombi . Right atrium . Thrombus . CVC . Tunnelled . Fistula . Arteriovenous . KFRT . Children
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00467-020-04743-9) contains supplementary material, which is available to authorized users. * Francis Calder [email protected] 1
Department of Paediatric Nephrology, Evelina London Children’s Hospital, London SE1 7EH, UK
2
Kings College London, London, UK
3
Department of Paediatric Cardiology, Evelina London Children’s Hospital, London, UK
4
Department of Intervention Radiology, Evelina London Children’s Hospital, London, UK
5
School of Biomedical Engineering & Imaging Scienc
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