Silicon carbide quantum dots for bioimaging
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Zsolt Szekrényes Institute for Solid State Physics and Optics, Wigner Research Centre for Physics, Hungarian Academy of Sciences, H-1121 Budapest, Hungary
Denes Pálfi The Faculty of Information Technology, Pázmány Péter Catholic University, H-1083 Budapest, Hungary; and Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary
Gergely Róna Institute of Enzymology, Research Centre of Natural Sciences, Hungarian Academy of Sciences, H-1113 Budapest, Hungary
István Balogh Institute for Solid State Physics and Optics, Wigner Research Centre for Physics, Hungarian Academy of Sciences, H-1121 Budapest, Hungary
Pal Andor Maák Department of Atomic Physics, Budapest University of Technology and Economics, H-1111 Budapest, Hungary
Gergely Katona Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary
Zsolt Czigány Institute for Technical Physics and Materials Science, Research Centre of Natural Sciences, Hungarian Academy of Sciences, H-1121 Budapest, Hungary
Katalin Kamarás Institute for Solid State Physics and Optics, Wigner Research Centre for Physics, Hungarian Academy of Sciences, H-1121 Budapest, Hungary
Balazs Rózsa The Faculty of Information Technology, Pázmány Péter Catholic University, H-1083 Budapest, Hungary; and Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary
Laszlo Buday and Beata Vértessy Institute of Enzymology, Research Centre of Natural Sciences, Hungarian Academy of Sciences, H-1113 Budapest, Hungary
Adam Gali Institute for Solid State Physics and Optics, Wigner Research Centre for Physics, Hungarian Academy of Sciences, H-1121 Budapest, Hungary; and Department of Atomic Physics, Budapest University of Technology and Economics, H-1111 Budapest, Hungary (Received 30 May 2012; accepted 10 August 2012)
Luminescent nanocrystals or quantum dots (QDs) have great potential for bioanalysis as well as optoelectronics. Here we report an effective and inexpensive fabrication method of silicon carbide quantum dots (SiC QDs), with diameter below 8 nm, based on electroless wet chemical etching. Our samples show strong violet-blue emission in the 410–450 nm region depending on the solvents used and particle size. The cytotoxic properties of the SiC QDs based on alamarBlueTM assay cells were studied. The presence of the QDs dots does not affect cell growth in a wide concentration range. Two-photon excitation showed significant response from SiC nanocrystals that were injected into hippocampal CA1 pyramidal cells.
I. INTRODUCTION
The present revolution in basic and applied biological research, like drug delivery or bioimaging techniques, strongly depends on the availability of nanosized crystals
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Address all correspondence to this author. e-mail: [email protected] DOI: 10.1557/jmr.2012.296 J. Mater. Res., 2012
Ó Materials Research Society 2012
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D. Beke et al.: Silicon carbide quantum dots for bioimaging
with adequate attributes linked especially to their nontoxic and bioinert propert
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