Sirolimus
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Oedema: 2 case reports Two female renal transplant recipients developed oedema during treatment with sirolimus [rapamycin; dosages, routes, indications and durations of therapy not stated]. The first woman, aged 54 years, had received a kidney transplant 13 years previously. She presented with acute hypoxic respiratory failure, having felt increasingly unwell for the last 3 weeks. She was intubated in the ICU and found to have pleural and pericardial effusion with massive anasarca. Aspirated pleural fluid revealed an exudate, and she was diagnosed with oedema secondary to sirolimus. The drug was switched to ciclosporin and her oedema resolved over 2–3 months. The second patient, a 61-year-old woman, presented with increasing dyspnoea 15 years after renal transplantation. Chest x-ray and echocardiogram showed pleural effusion and pericardial effusion. Fluid was removed via pericardiocentesis, but reaccumulated quickly. She was diagnosed with sirolimus-induced oedema and the drug was switched to ciclosporin. Her effusions resolved over several months. Klassen J. Unusual Complications Due to Rapamycin In Two Long Term Stable Renal Transplant Patients. 23rd International Congress of the Transplantation Society : abstr. P21.15, 15 Aug 2010. Available from: URL: http:// 803036543 www.transplantation2010.org - Canada
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Reactions 4 Sep 2010 No. 1317
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