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Acute kidney injury: 2 case reports In a single-center retrospective cohort study (involving 170 patients) conducted between 2015–2018 at the first affiliated hospital of Chongqing medical university, China, from January 2015 to December 2018, two elderly women [exact ages not stated] were described, who developed acute kidney injury during treatment with zoledronic acid and sodium chloride. The women were admitted due to osteoporosis. They received hydration with 250 mL of 0.9% sodium chloride solution. Additionally, they received an infusion of IV zoledronic acid [Aclasta; zoledronate] 5 mg/100mL injection for more than 15min. Hydration infusion rate was controlled at 40 to 60 drops/min. Hydration was paused at the half of the hydration treatment volume and changed to infusion of zoledronic acid. After the end of zoledronic acid infusion, the remaining hydration amount was continued. Within 24 hours after initiation of the treatment, the women exhibited elevation in their serum creatinine levels by 30 µmol/L and 44 µmol/L, respectively, consistent with acute kidney injury. During the treatment, they were treated with unspecified hydration therapy and unspecified diuretics. Subsequently, they were discharged. Prior to discharge, the blood serum creatinine level decreased. Their serum creatinine returned to the baseline after about 1 and 2 months, respectively. Dai X, et al. Effect of different hydration doses on renal function in patients with primary osteoporosis treated with zoledronic acid: A hospital-based retrospective cohort 803497411 study. Medicine 99: No. 25, 19 Jun 2020. Available from: URL: http://doi.org/10.1097/MD.0000000000020831

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Reactions 22 Aug 2020 No. 1818