Solid serous microcystic adenoma of the pancreas
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Solid serous microcystic adenoma of the pancreas Jordan R Stern1, Wendy L Frankel2, E Christopher Ellison1 and Mark Bloomston*1 Address: 1Department of Surgery, The Ohio State University, 410 W 10th Ave, N924 Doan, Columbus OH 43210, USA and 2Department of Pathology, The Ohio State University, Columbus OH 43210, USA Email: Jordan R Stern - [email protected]; Wendy L Frankel - [email protected]; E Christopher Ellison - [email protected]; Mark Bloomston* - [email protected] * Corresponding author
Published: 5 March 2007 World Journal of Surgical Oncology 2007, 5:26
doi:10.1186/1477-7819-5-26
Received: 11 December 2006 Accepted: 5 March 2007
This article is available from: http://www.wjso.com/content/5/1/26 © 2007 Stern et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background: Cystic neoplasms of the pancreas are less common than solid tumors, and portend a better prognosis. They can be divided into serous and mucinous subtypes, with the former behaving less aggressively and generally considered benign. Of the serous neoplasms, serous microcystic adenoma is the most common. An extremely rare solid variant of serous microcystic adenoma lacking secretory capability has been described. Herein, we present the fourth described case of this solid variant and review the literature. Case presentation: We present a case of a 62 year-old man with a history of abdominal pain, who on CT scan was found to have a solid mass at the junction of the head and body of the pancreas. The patient was offered resection for diagnosis and treatment, and subsequently underwent distal pancreatectomy and splenectomy. Based on gross pathology, histology and immunohistochemistry, the mass was determined to be a solid serous microcystic adenoma. Conclusion: Solid serous microcystic adenoma shows similar histologic and immunohistologic features to its classic cystic counterpart, but lacks any secretory functionality. It appears to behave in a benign manner, and as such, surgical resection is curative for patients with this tumor. Furthermore, until more cases of solid SMA are identified to further elucidate its natural history and improve the reliability of preoperative diagnosis, surgical resection of this solid pancreatic tumor should be considered standard therapy in order to exclude malignancy.
Background Tumors of the pancreas generally portend a poor prognosis, the majority of these being highly malignant ductal adenocarcinomas [1]. Much less common are the pancreatic cystic neoplasms, which include serous and mucinous subtypes, among others. Together these comprise only 1– 2% of all pancreatic exocrine tumors [2]. Architecturally, the serous cystic tumors are comprised of cuboidal cells arising from the pancreatic ducta
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