Solid State NMR Study of the Mixing Degree Between Ginkgo Biloba Extract and a Soy-Lecithin-Phosphatidylserine in a Comp
- PDF / 910,445 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 6 Downloads / 160 Views
ORIGINAL ARTICLE
Solid State NMR Study of the Mixing Degree Between Ginkgo Biloba Extract and a Soy‑Lecithin‑Phosphatidylserine in a Composite Prepared by the Phytosome® Method Elisa Carignani1 · Marco Geppi1,3 · Marco Lovati2 · Eric de Combarieu2 · Silvia Borsacchi3 Received: 26 April 2020 / Accepted: 13 July 2020 © The Author(s) 2020
Abstract Leaves extract of Ginkgo biloba, known in China since the most ancient times, has been widely used in the area of senile dementia thanks to its improving effects on cognitive function. A promising formulation of this botanical ingredient consists in a Ginkgo biloba-soy-lecithin-phosphatidylserine association obtained by the Phytosome® process. The precise assessment of the mixing degree between Ginkgo biloba and soy-lecithin-phosphatidylserine in this formulation is an important piece of information for understanding the reasons of its final performances. To this aim in the present study we carried out for the first time a Solid State Nuclear Magnetic Resonance investigation on Ginkgo biloba-soy-lecithin-phosphatidylserine association, on its constituents and on a mechanical mixture. The analysis of different observables highlighted a very intimate mixing (domains of single components not larger than 60 nm) of Ginkgo biloba and soy-lecithin-phosphatidylserine in their association obtained by P hytosome® process, together with a slight modification of their molecular dynamics, not observed in the case of the mechanical mixture. Keywords 1H relaxation times · Lipid dispersion · Solid state NMR · NMR spectroscopy · Dynamics · Phospholipids · 1H spin diffusion
1 Introduction Ginkgo biloba L. has been used in Chinese medicine since the most ancient times, while its pharmacological properties have been investigated in Europe only in the last decades [1]. The Ginkgo biloba tree is one of the oldest plants in the world and it is often defined as a “living fossil”, being the only surviving species of the Ginkgoaceae family, originated 150 millions years ago. As reported in a review by DeFeudis [2], Ginkgo biloba, thanks to its composition including several active compounds, has a “polyvalent” character. * Marco Geppi [email protected] 1
Dipartimento Di Chimica E Chimica Industriale, Università Di Pisa, via G. Moruzzi 13, 56124 Pisa, Italy
2
QC R&D Laboratories, Indena S.P.A., Via Don Minzoni 6, 20090 Settala, MI, Italy
3
Istituto Di Chimica Dei Composti OrganoMetallici, Consiglio Nazionale Delle Ricerche, CNR, S.S. Di Pisa, via G. Moruzzi 1, 56124 Pisa, Italy
Currently Ginkgo biloba leaves extract (GB) is especially indicated for treating cerebral insufficiency, that is a series of symptoms as lack of short term memory, confusion, apathy, affective and somatic problems, which can be related to altered cerebral circulation and ageing and are considered as early signs of senile dementia [3]. Indeed several specific terpenoids and flavonoids of GB are considered responsible for cognitive improvements, which can be particularly important in treating senile dem
Data Loading...
