Somatostatin receptor scintigraphy in sarcoidosis
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POSTER PRESENTATION
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Somatostatin receptor scintigraphy in sarcoidosis Lieke SJ Kamphuis1,2*, Dik J Kwekkeboom3, Jan AM van Laar1,2, Paul LA van Daele1,2, G Seerp Baarsma4, P Martin van Hagen1,2,4 From 6th European Workshop on Immune-Mediated Inflammatory Diseases Nice, France. 23-25 November 2011 Background Sarcoidosis is a multisystem granulomatous disorder, most frequently involving the lungs, skin or eyes. Somatostatin receptor scintigraphy (SRS) can localize granulomas by binding to somatostatin receptors that are expressed in sarcoidosis. We studied the patterns of uptake on SRS and correlated them to other disease parameters. Material and methods 218 patients were studied. The degree of intensity of uptake and localization of sarcoidosis associated lesion (SAL) were determined. The degree of intensity was compared with serum angiotensin converting enzyme (ACE) and serum soluble interleukin-2 receptor (sIL-2R). Elevated levels of serum ACE and sIL-2R have been shown to be associated with active sarcoidosis. Typical patterns on SRS were compared to conventional chest CT-scans and x-rays. Results SRS was negative in 28 patients, 10 patients had one -and 180 patients had more SALs. The degree of intensity correlated significantly with higher serum levels of ACE (p = 0.001) and serum levels of sIL-2R (p
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