Some effects of CNS cholinergic neurons on memory
The aim of this study is to observe the relationship between the impairment in passive avoidance task induced in rats by the i. p. administration of muscarinic antagonists, scopolamine and methyl-scopolamine, and the change in acetylcholine (ACh) output i
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c. G. Gott/ries and S. Nakamura (eds.)
Neurotransmitter and Dementia Springer-Verlag Wien GmbH
Prof. Dr. C. G. Gottfries Department of Psychiatry and Neurochemistry, Gothenburg University, Hisings Backa, Sweden
Prof. Dr. S. Nakamura 3rd Division of Internal Medicine, Hiroshima University Hospital, Hiroshima, Japan
This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machines or similar means, and storage in data banks. © 1990 by Springer-Verlag Wien Originally published by Springer-Verlag Wien in 1990 Printed on acid-free paper
With 44 Figures
ISBN 978-3-211-82190-9 ISBN 978-3-7091-3345-3 (eBook) DOI 10.1007/978-3-7091-3345-3
Preface Since three groups revealed a decrease in choline acetyltransferase activity in the Alzheimer brain in 1976, much attention has been focussed on neurotransmitter abnormality in Alzheimer's disease. Neurotransmitters are important in neuropsychiatric diseases because of their role in the pathogenesis of these diseases; at the same time, drugs that influence their metabolism may have particular significance in the treatment. In the past ten or more years, hundreds of reports have appeared on the abnormalities of various neurotransmitters in Alzheimer's disease although therapeutic trials on Alzheimer's disease through neurotransmitters have not hitherto been successful. Recently, strategies on neurotransmitter abnormality have widened as a result of new methodologies of molecular biology, including elucidation of structures of receptor-channels, receptor-mediated polyphosphoinositide metabolism or metabolism of enzymes related to neurotransmi tters. Many efforts have been made in the search for new openings in neurotransmitter research on Alzheimer's disease. It is timely, therefore, that Prof. Hasegawa, the president of the Fourth Congress of the International Psychiatric Association (IPA) has arranged publication of the Symposium "Neurotransmitter and Dementia" (held at the IV IPA Congress, Tokyo, September 6-8, 1989) as a Supplement to the "Journal of Neural Transmission". We have edited articles presented at the symposium and we are sure that this book will help to lead the way to a therapeutic breakthrough as well as clarification of the disease. Finally we would like to express our many thanks to Prof. Dr. A. Carlsson, Managing Editor and Prof. Dr. P. Riederer, Coordinating Editor of "Journal of Neural Transmission", and also to Springer-Verlag Wien, especially Mr. Frank Chr. May.
c. G. Gottfries
S. Nakamura
Contents Goto, T., Kuzuya, F., Endo, H., Tajima, T., Ikari, H.: Some effects of CNS cholinergic neurons on memory . . . . . . . . . . . . . . . . . . . .. Nakamura, S., Kawashima, S., Nakano, S., Tsuji, T., Araki, W.: Subcellular distribution of acetylcholinesterase in Alzheimer's disease: abnormallocalization and solubilization. . . . . . . . . . . . . . . . . . . . . . . . .. Ikeda, Y., O
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