Sorafenib
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Gastrointestinal perforation in an elderly patient?: case report A 78-year-old man started receiving oral sorafenib 800 mg/day and S-1 for renal cell carcinoma. Twelve days later, his serum and urinary levels of granulocyte colony-stimulating factor decreased to 175 and 143 pg/mL, respectively. One month after starting therapy, he died of hypovolaemic shock. His cause of death was found to be peritonitis caused by gastrointestinal perforation on autopsy. Author comment: "This event was identified in the counterpart of the site of tumor invasion, suggesting that the cause was mechanical damage as well as an additional damage resulting from inhibition of vascular endothelial growth factor by sorafenib." Kyono Y, et al. Combination therapy with sorafenib and S-1 for renal cell carcinoma producing granulocyte colony-stimulating factor. International Journal of Clinical Oncology 16: 275-278, No. 3, Jun 2011. Available from: URL: http:// 803062803 dx.doi.org/10.1007/s10147-010-0126-x - Japan
0114-9954/10/1378-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 19 Nov 2011 No. 1378
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