Spatial heterogeneity of bacterial colonization across different gut segments following inter-species microbiota transpl
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RESEARCH
Open Access
Spatial heterogeneity of bacterial colonization across different gut segments following inter-species microbiota transplantation Na Li1, Bin Zuo1, Shimeng Huang1, Benhua Zeng2, Dandan Han1, Tiantian Li1, Ting Liu1, Zhenhua Wu1, Hong Wei3*, Jiangchao Zhao4* and Junjun Wang1*
Abstract Background: The microbiota presents a compartmentalized distribution across different gut segments. Hence, the exogenous microbiota from a particular gut segment might only invade its homologous gut location during microbiota transplantation. Feces as the excreted residue contain most of the large-intestinal microbes but lack small-intestinal microbes. We speculated that whole-intestinal microbiota transplantation (WIMT), comprising jejunal, ileal, cecal, and colonic microbiota, would be more effective for reshaping the entire intestinal microbiota than conventional fecal microbiota transplantation fecal microbiota transplantation (FMT). (Continued on next page)
* Correspondence: [email protected]; [email protected]; [email protected] 1 State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China 2 Department of Laboratory Animal Science, College of Basic Medical Sciences, Third Military Medical University, Chongqing 400038, China 3 State Key Laboratory of Agricultural Microbiology, Key Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction of the Ministry of Education, and Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture and Rural Affairs, College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Li et al. Microbiome
(2020) 8:161
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Results: We modeled the compartmentalized colonization of the gut microbiota via transplanting the microbiota from jejunum, ileum, cecum, and
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