Special characteristics, reproductive, and clinical profile of women with unexplained infertility versus other causes of
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ASSISTED REPRODUCTION TECHNOLOGIES
Special characteristics, reproductive, and clinical profile of women with unexplained infertility versus other causes of infertility: a comparative study Charalampos Siristatidis 1,2
&
Abraham Pouliakis 3
&
Theodoros N. Sergentanis 4
Received: 10 October 2019 / Accepted: 28 May 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose To investigate whether women with unexplained infertility (UI) demonstrate different demographic and IVF characteristics compared to those with other causes of infertility. Methods Data on 245 couples that underwent a total of 413 IVF/ICSI cycles were analyzed (UI 114 cycles, 73 women; anovulation (PCO/PCOS) 83 cycles, 51 women; tubal factor 85 cycles, 47 women; male factor 131 cycles, 74 women). Features of UI were compared versus other infertility groups, after adjustment for multiple comparisons. Generalized least squares (GLS) and random-effects logistic regression analysis were also performed. Results Live birth rates, consisting of the primary outcome, were similar in all compared infertility groups. Compared to male infertility, UI was associated with woman’s older age at cycle, lower body mass index (BMI), and higher follicle-stimulating hormone (FSH). Compared to tubal infertility, UI was linked to lower endometrial thickness at oocyte retrieval and lower BMI; compared to anovulatory infertility related to PCO/PCOS, UI was linked to woman’s older age, more frequent smoking, and poorer ovarian reserve tests (FSH and antral follicle count). After adjustment for other types of infertility, woman’s age, age at menarche, and FSH levels, anovulatory infertility presented with higher odds of clinical pregnancy compared to UI (adjusted OR = 2.13, 95% C: 1.01–4.52). Conclusions Infertile women with UI undergoing assisted reproduction demonstrate different demographic and clinical characteristics compared to those of other causes of infertility, albeit live birth rates are similar. Keywords Unexplained infertility . Ovarian reserve . Assisted Reproduction . Live birth . Male infertility . tubal infertility.
Introduction * Charalampos Siristatidis [email protected] 1
Assisted Reproduction Unit, Third Department of Obstetrics and Gynecology, Medical School, National and Kapodistrian University of Athens, “Attikon” University Hospital, 1 Rimini Street, Chaidari, 12642 Athens, Greece
2
Assisted Reproducton Unit, Second Department of Obstetrics and Gynecology, Aretaieion Hospital, National and Kapodistrian University of Athens, Athens, Greece
3
Second Department of Pathology, Medical School, National and Kapodistrian University of Athens, “Attikon” University Hospital, 1 Rimini Street, Chaidari, 12642 Athens, Greece
4
Department of Clinical Therapeutics, Medical School, National and Kapodistrian University of Athens, “Alexandra” Hospital, 80 Vas. Sofias Ave, 11528 Athens, Greece
Unexplained infertility (UI) refers to a diagnosis made in couples in whom standard investigations including semen analysis, tests
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