Sphingolipids in Acute Lung Injury
Acute lung injury is a life-threatening disease that is characterized by pulmonary inflammation, loss of barrier functions, and hypoxemia. Sphingolipids are critically involved in the disease process that they can both expedite and extenuate: They expedit
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Erich Gulbins Irina Petrache Editors
Sphingolipids in Disease
Handbook of Experimental Pharmacology Volume 216
Editor-in-Chief F.B. Hofmann, München
Editorial Board J.E. Barrett, Philadelphia J. Buckingham, Uxbridge V.M. Flockerzi, Homburg D. Ganten, Berlin P. Geppetti, Florence M.C. Michel, Ingelheim P. Moore, Singapore C.P. Page, London W. Rosenthal, Berlin
For further volumes: http://www.springer.com/series/164
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Erich Gulbins • Irina Petrache Editors
Sphingolipids in Disease
Editors Erich Gulbins Department of Molecular Biology University of Duisburg-Essen Essen Germany
Irina Petrache Division of Pulmonary, Allergy, Critical Care and Occupational Medicine Department of Medicine Indiana University School of Medicine Indianapolis, IN, USA
ISSN 0171-2004 ISSN 1865-0325 (electronic) ISBN 978-3-7091-1510-7 ISBN 978-3-7091-1511-4 (eBook) DOI 10.1007/978-3-7091-1511-4 Springer Wien Heidelberg New York Dordrecht London Library of Congress Control Number: 2013935589 # Springer-Verlag Wien 2013 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
Until the late 1980s, sphingolipids were believed to represent structural components of the plasma membrane, whose function was to provide a protective barrier to the cell. This picture dramatically changed w
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