Spike-sorting analysis of neural electrical signals evoked by acupuncture based on model
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RESEARCH ARTICLE
Spike-sorting analysis of neural electrical signals evoked by acupuncture based on model Qing Qin1 • Yajiao Liu2 • Bonan Shan3 • Yanqiu Che1 • Chunxiao Han1 • Yingmei Qin1 • Ruofan Wang1 Jiang Wang2
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Received: 18 January 2020 / Revised: 6 October 2020 / Accepted: 24 October 2020 Ó Springer Nature B.V. 2020
Abstract Acupuncturing the Zusanli (ST 36) point with different types of manual acupuncture manipulations (MAs) and different frequencies can evoke a lot of neural response activities in spinal dorsal root neurons. The action potential is the basic unit of communication in the neural response process. With the rapid development of the electrode acquisition technology, we can simultaneously obtain neural electrical signals of multiple neurons in the target area. So it is crucial to extract spike trains of each neuron from raw recorded data. To solve the problem of variability of the spike waveform, this paper adopts a optimization algorithm based on model to improve the wave-cluster algorithm, which can provide higher accuracy and reliability. Further, through this optimization algorithm, we make a statistical analysis on spike events evoked by different MAs. Results suggest that numbers of response spikes under reinforcing manipulations are far more than reducing manipulations, which mainly embody in synchronous spike activities. Keywords Acupuncture Neural electrical signal Action potential Sorting
Introduction Acupuncture as an essential part of traditional Chinese medicine (TCM) has been widely accepted with the significant clinical effect (Takeda and Wessel 1994; Andersson and Lundeberg 1995; Leake and Broderick 1999; Kaplinsky and Barton 2004). In recent years, with the integration of TCM and Western medicine, researchers tried to understand the in-depth mechanisms of acupuncture from the perspectives of anatomy, neuro-physiology and computational neuron, which leaded acupuncture into the field of modern science (Kristin and Yi 2009). Now,
& Jiang Wang [email protected] 1
Tianjin Key Laboratory of Information Sensing & Intelligent Control, School of Automation and Electrical Engineering, Tianjin University of Technology and Education, Tianjin, People’s Republic of China
2
School of Electrical and Information Engineering, Tianjin University, Tianjin, People’s Republic of China
3
China Academy of Electronics and Information Technology, Beijing, People’s Republic of China
there is a general consensus that acupuncturing the Zusanli (ST 36) point can evoke the effect in the corresponding target organ by modulating the nervous system, the endocrine system and the whole-body fluid system (Zhang and Zhang 2007). Manual acupuncture manipulations (MAs) are fundamental to the clinical efficacy of acupuncture (Yang et al. 2006). Stimuli with different MAs can make the nervous system produce different response activities correspondingly, and finally results of the regulation of the human body are also different (Shi 1998; Hu and Yang 200
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