Strategies for Enhanced, MRI-Guided Targeting of Stem Cells to Stroke Lesions
The development of effective strategies for the treatment of stroke is one of the potential applications of stem cell therapy. Various transplantation methods, cell types, and animal models have been examined to investigate the potential benefits of stem
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Jukka Jolkkonen • Piotr Walczak Editors
Cell-Based Therapies in Stroke
Editors Jukka Jolkkonen Institute of Clinical Medicine – Neurology University of Eastern Finland Kuopio Finland
Piotr Walczak School of Medicine Department of Radiology Johns Hopkins University Baltimore, Maryland USA
ISBN 978-3-7091-1174-1 ISBN 978-3-7091-1175-8 DOI 10.1007/978-3-7091-1175-8 Springer Heidelberg New York Dordrecht London
(eBook)
Library of Congress Control Number: 2013930553 © Springer-Verlag Wien 2013 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
Stroke is a major cause of severe disability that poses an enormous healthcare burden. The only effective therapy is thrombolysis when started within 4.5 h of symptoms onset, but, because of the narrow therapeutic time window, only few patients benefit from it. Despite extensive research, neuroprotective drugs have all failed in clinical trials. Thus, efforts focused on the pursuit of new cell-based restorative therapies have emerged recently as attractive approaches for the treatment of stroke patients. Indeed, the preclinical data regarding cell transplantation show great potential. However, in light of so many failed neuroprotective strategies, these promising results should be evaluated vigilantly before clinica
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