Strict bladder filling and rectal emptying during prostate SBRT: Does it make a dosimetric or clinical difference?
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RESEARCH
Strict bladder filling and rectal emptying during prostate SBRT: Does it make a dosimetric or clinical difference? David J. Byun1, Daniel J. Gorovets2, Lauren M. Jacobs2, Laura Happersett3, Pengpeng Zhang3, Xin Pei4, Sarah Burleson3, Zhigang Zhang4, Margie Hunt3, Sean McBride2, Marisa A. Kollmeier2 and Michael J. Zelefsky2* Prior presentations: This abstract was presented at the 2016 American Society for Radiation Oncology Meeting, September 25–28, 2016 in Boston, Massachusetts.
Abstract Background: To evaluate inter-fractional variations in bladder and rectum during prostate stereotactic body radiation therapy (SBRT) and determine dosimetric and clinical consequences. Methods: Eighty-five patients with 510 computed tomography (CT) images were analyzed. Median prescription dose was 40 Gy in 5 fractions. Patients were instructed to maintain a full bladder and empty rectum prior to simulation and each treatment. A single reviewer delineated organs at risk (OARs) on the simulation (Sim-CT) and Cone Beam CTs (CBCT) for analyses. Results: Bladder and rectum volume reductions were observed throughout the course of SBRT, with largest mean reductions of 86.9 mL (19.0%) for bladder and 6.4 mL (8.7%) for rectum noted at fraction #5 compared to Sim-CT (P
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