Structure of SARS-CoV-2 main protease in the apo state
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ructure of SARS-CoV-2 main protease in the apo state 1†
2,3†
4,5
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Xuelan Zhou , Fanglin Zhong , Cheng Lin , Xiaohui Hu , Yan Zhang , Bing Xiong , 8,9 10 2 11 12 13 Xiushan Yin , Jinheng Fu , Wei He , Jingjing Duan , Yang Fu , Huan Zhou , 14 13* 2,3* 1* Peter J. McCormick , Qisheng Wang , Jian Li & Jin Zhang 1
School of Basic Medical Sciences, Nanchang University, Nanchang 330031, China; College of Pharmaceutical Sciences, Gannan Medical University, Ganzhou 341000, China; 3 Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical 2
University, Ganzhou 341000, China; Shenzhen Crystalo Biopharmaceutical Co., Ltd, Shenzhen 518118, China; 5 Jiangxi Jmerry Biopharmaceutical Co., Ltd, Ganzhou 341000, China; 6 The Second Affiliated Hospital of Nanchang University, Nanchang 330031, China; 7 Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; 8 Applied Biology Laboratory, Shenyang University of Chemical Technology, Shenyang 110142, China; 9 Biotech & Biomedicine Science (Jiangxi) Co. Ltd, Ganzhou 341000, China; 10 Jiangxi-OAI Joint Research Institution, Nanchang University, Nanchang 330047, China; 11 Human Aging Research Institute (HARI), School of Life Sciences, Nanchang University, Nanchang 330031, China; 12 School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China; 13 Shanghai Synchrotron Radiation Facility, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201204, China; 14 Centre for Endocrinology, William Harvey Research Institute, Bart’s and the London School of Medicine and Dentistry, Queen Mary, 4
University of London, London EC1M 6BQ, UK Received June 28, 2020; accepted August 1, 2020; published online September 1, 2020
Citation:
Zhou, X., Zhong, F., Lin, C., Hu, X., Zhang, Y., Xiong, B., Yin, X., Fu, J., He, W., Duan, J., et al. (2020). Structure of SARS-CoV-2 main protease in the apo state. Sci China Life Sci 63, https://doi.org/10.1007/s11427-020-1791-3
Dear Editor, Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a global pandemic that severely threatens global health with concordant economic damage. However, there is currently no clinically approved vaccines or drugs against COVID-19 (Lu et al., 2020). SARS-CoV-2 main protease pro pro (M , also called 3C-like protease, 3CL ) mediates the proteolytic processing of large replicase polyprotein 1a (pp1a) and pp1ab into non-structural proteins (NSPs) at pro eleven conservative sites (Zumla et al., 2016). Thus, M is †Contributed equally to this work *Corresponding authors (Qisheng Wang, email: [email protected]; Jian Li, email: [email protected]; Jin Zhang, email: [email protected])
of considerable interest as a drug target in the treatment of COVID-19 since the proteolytic activity of this viral protease is essential for viral replication. Mutational and structural studies
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