Study design and baseline characteristics of a population-based prospective cohort study of dementia in Japan: the Japan
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(2020) 25:64
RESEARCH ARTICLE
Environmental Health and Preventive Medicine Open Access
Study design and baseline characteristics of a population-based prospective cohort study of dementia in Japan: the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) Toshiharu Ninomiya1* , Shigeyuki Nakaji2, Tetsuya Maeda3, Masahito Yamada4, Masaru Mimura5, Kenji Nakashima6, Takaaki Mori7, Minoru Takebayashi8, Tomoyuki Ohara9, Jun Hata1, Yoshihiro Kokubo10, Kazuhiro Uchida11, Yasuyuki Taki12, Shuzo Kumagai13, Koji Yonemoto14, Hisako Yoshida15, Kaori Muto16, Yukihide Momozawa17, Masato Akiyama18, Michiaki Kubo19, Manabu Ikeda20, Shigenobu Kanba9, Yutaka Kiyohara19 and on behalf of the JPSFC-AD Study Group
Abstract Background: The burden of dementia is growing rapidly and has become a medical and social problem in Japan. Prospective cohort studies have been considered an effective methodology to clarify the risk factors and the etiology of dementia. We aimed to perform a large-scale dementia cohort study to elucidate environmental and genetic risk factors for dementia, as well as their interaction. Methods: The Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) is a multisite, populationbased prospective cohort study of dementia, which was designed to enroll approximately 10,000 community-dwelling residents aged 65 years or older from 8 sites in Japan and to follow them up prospectively for at least 5 years. Baseline exposure data, including lifestyles, medical information, diets, physical activities, blood pressure, cognitive function, blood test, brain magnetic resonance imaging (MRI), and DNA samples, were collected with a pre-specified protocol and standardized measurement methods. The primary outcome was the development of dementia and its subtypes. The diagnosis of dementia was adjudicated by an endpoint adjudication committee using standard criteria and clinical information according to the Diagnostic and Statistical Manual of Mental Disorders, 3rd Revised Edition. For brain MRI, three-dimensional acquisition of T1-weighted images was performed. Individual participant data were pooled for data analyses. (Continued on next page)
* Correspondence: [email protected] 1 Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the a
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