Study of Afterglow and Thermoluminescence Properties of Synthetic Opal-C Nanoparticles for In Vivo Dosimetry Application
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Study of Afterglow and Thermoluminescence Properties of Synthetic Opal-C Nanoparticles for In Vivo Dosimetry Applications Marlen Hernández-Ortiz1a, Laura S. Acosta-Torres2, Rodolfo Bernal3, Catalina CruzVázquez1b and Víctor M. Castaño4. 1a Programa de Posgrado en Ciencia de Materiales del 1bDepartamento de Investigación en Polímeros y Materiales, Universidad de Sonora, A. P. 130, Hermosillo, Sonora 83000 México. 2 Escuela Nacional de Estudios Superiores, Universidad Nacional Autónoma de México, Unidad León, Boulevard UNAM No. 2011 Predio el Saucillo y el Potrero C.P. 36969. León Guanajuato, México. 3 Departamento de Investigación en Física, Universidad de Sonora, A. P. 5-088, Hermosillo, Sonora 83190 México. 4 Departamento de Ingeniería Molecular de Materiales, Centro de Física Aplicada y Tecnología Avanzada, Universidad Nacional Autónoma de México, Campus Juriquilla, Querétaro 76230 México. ABSTRACT Opal particles, with diameter ca. 80 nm, were synthesized by the Stöber method. Samples were exposed to 100 Gy of beta particle irradiation and its thermoluminescence (TL) emission was recorded. TL response presents good reproducibility, standard deviation 1 %. The glow curve displays two TL peaks 86 and 400 ºC and the afterglow (AG) phenomenon is observed immediately after irradiation (< 150ºC). The synthetic opal-C exhibits a linear dependence of AG response as function of dose from 0.25 to 8 Gy. This dose range is of interest for personal and clinical dosimetry. Moreover, a previous study indicates that cytotoxic and genotoxic effects caused by opal nanoparticles, did not induce unrepairable DNA damage neither a cellular harm. Therefore, our results show synthetic opal-C is a material useful for in vivo radiation dosimetry. INTRODUCTION Thermoluminescence (TL) is the emission of light from an insulator or semiconductor previously exposed to ionizing radiation when it is heated. The light emission intensity measured as a function of temperature provides a distinctive TL glow curve, resulting from radiative recombination and gives information of the trapping states of charge carriers created during irradiation and transfer processes [1]. The more widely spread and successful application of the TL is in the field of radiation dosimetry [2]. TL dosimetry allows to estimate the total dose absorbed by a phosphor material into a certain time interval, but do not allow to determine the instantaneous intensity of a radiation field. Moreover, in vivo dosimetry is important for verification of the actual dose delivered to the target volume and for real-time measurement of absorbed dose received during a treatment. To determine the dose of the skin of a patient undergoing radiotherapy depends on some parameters
that are difficult to take into account. A number of authors have investigated the surface dose in patients using a variety of different techniques. TL dosimeters (TLDs) are widely used as an important quality assurance tool for in vivo dosimetry, nevertheless, require pre-preparation and post-processing and TLDs do not
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