Study of Small Intestinal Bacterial Overgrowth in a Cohort of Patients with Abdominal Symptoms Who Underwent Bariatric S
- PDF / 320,924 Bytes
- 7 Pages / 595.276 x 790.866 pts Page_size
- 40 Downloads / 143 Views
ORIGINAL CONTRIBUTIONS
Study of Small Intestinal Bacterial Overgrowth in a Cohort of Patients with Abdominal Symptoms Who Underwent Bariatric Surgery Thomas Mouillot 1,2 & Nybel Rhyman 2 & Cyril Gauthier 3 & Justine Paris 4 & Anne-Sophie Lang 4 & Sarah Lepers-Tassy 1 & Sylvain Manfredi 2 & Côme Lepage 2 & Corinne Leloup 1 & Agnès Jacquin-Piques 1,5 & Marie-Claude Brindisi 1,6 & Laurent Brondel 1,2
# Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Introduction Small intestinal bacterial overgrowth (SIBO) is a common complication of bariatric surgery. Digestive decontamination treatments with oral antibiotic therapy vary and are not codified. This retrospective study was conducted to analyse the characteristics of bariatric surgery patients who underwent a glucose breath test (GBT) and to analyse the effectiveness of the antibiotic decontamination therapy. Materials and Methods A total of 101 operated patients (Roux-en-Y bypass (RYB), omega bypass (ΩB) and sleeve gastrectomy (SG)) who underwent a GBT (75 g/250 mL) were included. Anthropometric data, symptoms of SIBO, type of surgery, use of proton pump inhibitors (PPIs) and antibiotic therapy were analysed. The effectiveness of the antibiotic treatment, defined by improvement of the symptoms, was evaluated during the follow-up. Results Of the 85 women and 16 men included (48.5 ± 3.6 years old), 63 underwent RYB, 31 underwent ΩB and 7 underwent SG. The GBT was positive in 83% of the patients. A positive test was associated with age (p < 0.001), female sex (p < 0.01) and PPI use (p < 0.01), but there was no significant difference according to the type of surgery. Sixty-one percent of patients treated with gentamicin/metronidazole sequential antibiotic therapy and 58% of patients treated with metronidazole alone achieved treatment efficacy (with no significant difference in efficacy between these treatments). Conclusion SIBO should be systematically considered in the context of abdominal symptoms in bariatric surgery patients, regardless the type of surgery, particularly in patients who are older or female and after PPI treatment. Digestive decontamination appears to be similar between gentamycin/metronidazole and metronidazole treatments. Keywords Antibiotic therapy . Bariatric surgery . Glucose breath test . Obesity . Small intestinal bacterial overgrowth (SIBO)
* Thomas Mouillot [email protected] 1
Centre des Sciences du Goût et de l’Alimentation, AgroSup Dijon, CNRS, INRAE, Université Bourgogne Franche-Comté, F-21000 Dijon, France
2
Service d’hépato-gastro-entérologie, CHU F. Mitterrand, F-21000 Dijon, France
3
Espace Médical Nutrition et Obésité, Ramsay Santé, 4 rue Lounes Matoub, F-21000, Dijon, France
4
Service de Pharmacie, CHU F. Mitterrand, F-21000 Dijon, France
5
Service de neurophysiologie clinique, CHU F. Mitterrand, F-21000 Dijon, France
6
Service d’endocrinologie et diabétologie, CHU F. Mitterrand, F-21000 Dijon, France
Introduction Small intestinal bacterial overgrowth (SIBO) is a heterogeneous patho
Data Loading...
