Synthesis and characterization of Se-based nanoparticles as potential generators of reactive oxygen species
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MRS Advances © 2019 Materials Research Society DOI: 10.1557/adv.2019.137
Synthesis and characterization of Se-based nanoparticles as potential generators of reactive oxygen species Nadja Maldonado-Luna1, Sonia Bailón-Ruiz2, Myrna Reyes-Blas3, and Oscar J. PeralesPerez4 1
Department of Mechanical Engineering, University of Puerto Rico at Mayaguez
2
Department of Chemistry and Physics, University of Puerto Rico at Ponce
3
Department of Chemistry, University of Puerto Rico at Mayaguez
4
Department of Engineering Sciences & Materials, University of Puerto Rico at Mayagüez
ABSTRACT
This work presents the synthesis of selenium-based nanoparticles via microwave-assisted heating and their subsequent characterization using UV-vis Spectroscopy (UV-Vis), highresolution transmission electron microscopy (HRTEM), and energy-dispersive X-ray spectroscopy (EDX), techniques. Ongoing research includes the study of the nanoparticles capacity to generate reactive oxygen species (ROS).
INTRODUCTION: The use of nanoparticles have become prominent in the biomedical field in the last few decades, giving rise to a new area that focuses on the development of nanomaterials for the prevention and treatment of different diseases [1–3]. Semiconducting nanoparticles (NPs) are promising photosensitizing materials for photodynamic therapy (PDT) applied to cancer cells due to their capability to generate cytotoxic reactive oxygen species (ROS) through a photo-stimulated chemical reaction [4–6]. There are many factors that can influence the generation of ROS by nanoparticles.
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Reduced particle size increases ROS production due to the larger specific surface area permitting a greater exposure to oxygen and light absorption. The functionalization of NPs can also affect its optical properties and promote the ROS generation [7]. In particular, the potential use of metal-based NPs for PDT are based on the enhanced interaction with enzymes and proteins in mammalian cells, interfering with their antioxidant capability and leading to the generation of ROS, and subsequent apoptosis or necrosis of cells [8]. Selenium is commonly used as an anti-fungal agent [9], and as a nutritional supplement in its inorganic and organic forms based on its strong antioxidant capacity. It exists in a variety of crystalline structures, from its most stable trigonal structure to a monoclinic and less stable structure [10]. Selenium can also be found in an amorphous form, being a mix of disordered chains. The synthesis of nano-selenium can be achieved by different methods, such as chemical [11] and bacterial reduction of Se(IV) solutions [1]. On the other hand, CdSe/S Quantum dots (QDs) are also synthesized through the same microwave-assisted approach for comparison purposes. These QDs are known to generate ROS in aqueous phase
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