Synthesis, optical properties and photherapy applications of gold nanostars
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REVIEW ARTICLE
Synthesis, optical properties and photherapy applications of gold nanostars Pervin Deveci1 Received: 27 July 2020 / Accepted: 6 November 2020 © Springer Nature B.V. 2020
Abstract Phototherapy is a type of medical treatment that involves exposure to ultraviolet-visible (UV–Vis) region or near-infrared (NIR) region light to treat certain medical conditions. Compared to other treatment methods such as chemotherapy and radiotherapy, it attracts a lot of attention today due to its lower cost, more effect on the tumor cell, and less side effects. Today’s clinical therapy research shows that combining chemotherapeutic methods and phototherapeutic methods on a single nanostructure increases the therapeutic effect that each method alone has, and this is even more effective in destroying cancer cells. The emergence of nanomaterials recently opens up new opportunities to increase therapeutic efficacy and overcome limitations in current phototherapy techniques. Gold nanostars (GNSs) are a kind of promising photothermal agent recently in the biomedical field with its strong absorption in the NIR field, high photothermal conversion efficiency, excellent photothermal stability, and biocompatibility. In this study, the synthesis methods, optical properties of GNSs, and their current studies on cancer diagnosis and treatments are summarized. Keywords Gold nanoparticle · Gold nanostar · Photothermal therapy · Photodynamic therapy · Cancer Abbreviations CS Chitosan CT X-ray computed tomography FDA Food and Drug Administration GNCs Gold nanocages GNP Gold nanoparticle GNPs Gold nanoparticles GNRs Gold nanorods GNS Gold nanostar GNSs Gold nanostars GSH Glutathione LSB Lauryl sulfobetaine LSPR Localized surface plasmon resonance MB Methylene blue MPS Mononuclear phagocytic system MRI Magnetic resonance imaging NIR Near-infrared NPs Nanoparticles PA N- (3-aminopropyl) methacrylamide hydrochloride * Pervin Deveci [email protected] 1
Faculty of Science, Department of Chemistry, Selcuk University, Konya 42031, Turkey
PAI Photoacoustic imaging PDT Photodynamic therapy PEG Polyethylene glycol PET Positron emission tomography PS Photosensitizer PTT Photothermal therapy SERS Surface-enhanced Raman spectroscopy SPR Surface plasmon resonance TEM Transmission electron microscopy UV–Vis Ultraviolet-visible
Highlights • Phototherapy is a type of medical treatment that involves
exposure to ultraviolet-visible region or near-infrared region light to treat certain medical conditions • Gold nanostars are a kind of promising photothermal agent recently in the biomedical field • The emergence of nanomaterials recently opens up new opportunities to increase therapeutic efficacy and overcome restrictions in current photothermal therapy and photodynamic therapy applications
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Introduction Cancer occurs as a result of excessive and uncontrolled proliferation of any group of cells in the body. While the World Health Organization data showed about 18.1 million new cancer cases i
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