Synthesis, structural investigations, DFT studies, and neurotrophic activity of zinc complex with a multidentate ligand
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ORIGINAL PAPER
Synthesis, structural investigations, DFT studies, and neurotrophic activity of zinc complex with a multidentate ligand Mohammad Azam1 · Saikh Mohammad Wabaidur1,5 · Saud I. Al‑Resayes1 · Mahboob Alam2 · Md. Nazmul Haque3,4 · Il Soo Moon4 · Rajendra5 Received: 24 April 2020 / Accepted: 23 September 2020 © Springer-Verlag GmbH Austria, part of Springer Nature 2020
Abstract A novel zinc complex derived from a multidentate ligand, nitrilotris(ethane-2,1-diyl)tris(azanylylidene)tris(methanylylidene)tris(2-methoxyphenol), was designed and structurally investigated by elemental analyses, IR, NMR, ESI-MS, and UV–Vis studies. The density functional theory was also recorded to investigate the additional insights into the structural and electronic properties of the ligand and its complex. Both the ligand and its complex showed significant neurite outgrowth and viability in brain neuron at lower concentration when investigated for neurological properties. Thus, it can be suggested that the ligand and its complex may play a potential role in brain development, functioning as well as in the treatment of neurological disorders. Graphic abstract
Keywords Zinc(II) complex · DFT studies · Neurotrophic activity
Introduction
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00706-020-02696-1) contains supplementary material, which is available to authorized users.
Schiff base ligands, also known as privileged ligands, show a broad range of applications, particularly in food chemistry, organic synthesis, dyes and pigments, catalysis, and various biological applications [1–7]. The biological behaviour
* Mohammad Azam [email protected]; [email protected]
2
Division of Chemistry and Biotechnology, Dongguk University, 123 Dongdae‑ro, Gyeongju, Republic of Korea
* Mahboob Alam [email protected]
3
Department of Fisheries Biology and Genetics, Patuakali Science and Technology University, Patuakhali 8602, Bangladesh
4
Department of Anatomy, School of Medicine, Dongguk University, Gyeongju 38066, Republic of Korea
5
Department of Chemistry, Banasthali Vidyapith, Banasthali 304022, Rajasthan, India
* Rajendra [email protected] 1
Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Kingdom of Saudi Arabia
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exhibited by Schiff bases is supposed to be due to the presence of azomethine/imine linkage [8–10]. Over the years, the chemistry of Schiff bases has received extensive attention in coordination chemistry due to their ease in synthesis, denticity, strong chelating behaviour, flexible structures and, more importantly, in the formation of numerous coordination compounds with multiple applications in medicinal and material chemistry [11–20]. Literature reveals that the metal complexes with coordination number seven or higher are less developed [21, 22]. However, heptadentate Schiff base complexes, particularly tripodal complexes, constructed from tris(2-aminoethyl)amin
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