Systems and Precision Medicine in Necrotizing Soft Tissue Infections

Necrotizing soft tissue infections (NSTI) are multifactorial and characterized by dysfunctional, time dependent, highly varying hyper- to hypo-inflammatory host responses contributing to disease severity. Furthermore, host-pathogen interactions are divers

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Anna Norrby-Teglund Mattias Svensson Steinar Skrede  Editors

Necrotizing Soft Tissue Infections Clinical and Pathogenic Aspects

Advances in Experimental Medicine and Biology Volume 1294 Series Editors Wim E. Crusio, Institut de Neurosciences Cognitives et Intégratives d’Aquitaine, CNRS and University of Bordeaux, Pessac Cedex, France Haidong Dong, Departments of Urology and Immunology, Mayo Clinic, Rochester, Minnesota, USA Heinfried H. Radeke, Institute of Pharmacology & Toxicology, Clinic of the Goethe University Frankfurt Main, Frankfurt am Main, Hessen, Germany Nima Rezaei, Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran Junjie Xiao, Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Science, School of Life Science, Shanghai University, Shanghai, China

Advances in Experimental Medicine and Biology provides a platform for scientific contributions in the main disciplines of the biomedicine and the life sciences. This series publishes thematic volumes on contemporary research in the areas of microbiology, immunology, neurosciences, biochemistry, biomedical engineering, genetics, physiology, and cancer research. Covering emerging topics and techniques in basic and clinical science, it brings together clinicians and researchers from various fields. Advances in Experimental Medicine and Biology has been publishing exceptional works in the field for over 40 years, and is indexed in SCOPUS, Medline (PubMed), Journal Citation Reports/Science Edition, Science Citation Index Expanded (SciSearch, Web of Science), EMBASE, BIOSIS, Reaxys, EMBiology, the Chemical Abstracts Service (CAS), and Pathway Studio. 2019 Impact Factor: 2.450 5 Year Impact Factor: 2.324

More information about this series at http://www.springer.com/series/5584

Anna Norrby-Teglund • Mattias Svensson • Steinar Skrede Editors

Necrotizing Soft Tissue Infections Clinical and Pathogenic Aspects

Editors Anna Norrby-Teglund Center for Infectious Medicine, Department of Medicine Karolinska Institutet Huddinge, Sweden

Mattias Svensson Center for Infectious Medicine, Department of Medicine Karolinska Institutet Huddinge, Sweden

Steinar Skrede Department of Clinical Science University of Bergen Bergen, Norway Department of Medicine Haukeland University Hospital Bergen, Norway

ISSN 0065-2598 ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-3-030-57615-8 ISBN 978-3-030-57616-5 (eBook) https://doi.org/10.1007/978-3-030-57616-5 # Springer Nature Switzerland AG 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descri