T-Cell Abnormalities
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by increased platelet destruction and reduced platelet production caused primarily by IgG antiplatelet autoantibodies, which mainly target platelet membrane glycoproteins (GPs), includin
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Yoji Ishida Yoshiaki Tomiyama Editors
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Autoimmune Thrombocytopenia
Yoji Ishida • Yoshiaki Tomiyama Editors
Autoimmune Thrombocytopenia
Editors Yoji Ishida Division of Hematology and Oncology Department of Internal Medicine Iwate Medical University School of Medicine Morioka Iwate Japan
Yoshiaki Tomiyama Department of Blood Transfusion Osaka University Hospital Suita Osaka Japan
ISBN 978-981-10-4141-9 ISBN 978-981-10-4142-6 (eBook) DOI 10.1007/978-981-10-4142-6 Library of Congress Control Number: 2017943031 © Springer Nature Singapore Pte Ltd. 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
Preface
Besides anemia, thrombocytopenia is the most common hematological abnormality encountered in daily clinical practice by general physicians as well as hematologists. The pathophysiology of thrombocytopenia is classified into at least three categories: (1) decreased platelet production, (2) increased platelet destruction or consumption, and (3) abnormal platelet distribution or pooling. Among them, autoimmune thrombocytopenia (ITP), the theme of this book, is a common disease caused by increased platelet destruction due to antiplatelet autoantibodies. However, its diagnosis is still difficult because of the lack of specific diagnostic tests. So far, its diagnosis is still based on differential diagnosis in daily practice. However, recent basic and clinical research has made a great progress in the pathophysiology and management of ITP as well as platelet/megakaryocyte biology. One of the major advances in the management of ITP is that the development of thrombopoietin receptor (TPO-R) agonists has indu
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