Target Organ Toxicology in Caenorhabditis elegans
This book introduces readers to intestinal and epidermal barriers, and to toxicity induction of environmental toxicants or stresses in the intestine, epidermis, neurons, muscle, and reproductive organs in Caenorhabditis elegans. In addition, it discu
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Target Organ Toxicology in Caenorhabditis elegans
Target Organ Toxicology in Caenorhabditis elegans
Dayong Wang
Target Organ Toxicology in Caenorhabditis elegans
Dayong Wang School of Medicine Southeast University Nanjing, China
ISBN 978-981-13-6009-1 ISBN 978-981-13-6010-7 (eBook) https://doi.org/10.1007/978-981-13-6010-7 Library of Congress Control Number: 2018967724 © Springer Nature Singapore Pte Ltd. 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
Preface
Nematode Caenorhabditis elegans is a classic model animal widely used in the study of life sciences. Meanwhile, it has been further frequently used for toxicity assessment and toxicological study of various environmental toxicants or stresses. One of the important reasons is the sensitivity of nematodes to various environmental exposures. The second reason is the conserved property for most of the molecular events and the signaling pathways between nematodes and mammals or human beings. The third reason is from the classic model animal properties of C. elegans with well-described genetic and developmental backgrounds and rich and available genetic and molecular resources. In nematodes, once exposed to environmental toxicants, the toxicants can enter the primary targeted organs (such as intestinal cells) and even be translocated into secondary targeted organs (such as reproductive organs and neurons). Structurally, C. elegans do not have some important organs (such as the heart, liver, lung, and kidney) due to the lack of the mesoderm during the development. Nevertheless, the C. elegans has epidermal system, nervous system, excretory system, muscle system, coelomocyte system, alimentary syst
