Targeted Therapies in Cancer Myth or Reality?
In September 2005 an International Meeting on “Targeted Therapies in Cancer: Myth or Reality” was held in Milan. This successful Meeting was intended to represent a forum for scientists and clinicians working in cancer drug discovery and therapy to share
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ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Editorial Board: NATHAN BACK, State University of New York at Buffalo IRUN R. COHEN, The Weizmann Institute of Science ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research JOHN D. LAMBRIS, University of Pennsylvania RODOLFO PAOLETTI, University of Milan
Recent Volumes in this Series Volume 602 OSTEOIMMUNOLOGY: INTERACTIONS OF THE IMMUNE AND SKELETAL SYSTEMS Edited by Yongwon Choi Volume 603 THE GENUS YERSINIA: FROM GENOMICS TO FUNCTION Edited by Robert D. Perry and Jacqueline D. Fetherson Volume 604 ADVANCES IN MOLECULAR ONCOLOGY Edited by Fabrizio d’Adda di Gagagna, Susanna Chiocca, Fraser McBlane and Ugo Cavallaro Volume 605 INTEGRATION IN RESPIRATORY CONTROL: FROM GENES TO SYSTEMS Edited by Marc Poulin and Richard Wilson Volume 606 BIOACTIVE COMPONENTS OF MILK Edited by Zsuzsanna Bosze Volume 607 EUKARYOTIC MEMBRANES AND CYTOSKELETON: ORIGINS AND EVOLUTION Edited by Gáspár Jékely Volume 608 BREAST CANCER CHEMOSENSITIVITY Edited by Dihua Yu and Mien-Chie Hung Volume 609 HOT TOPICS IN INFECTION AND IMMUNITY IN CHILDREN VI Edited by Adam Finn and Andrew J. Pollard Volume 610 TARGETED THERAPIES IN CANCER Edited by Francesco Colotta and Alberto Mantovani A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher.
Francesco Colotta Alberto Mantovani Editors
Targeted Therapies in Cancer: Myth or Reality?
Francesco Colotta Nerviano Medical Sciences 10 Viale Pasteur Nerviano (Milano) 20014, Italy [email protected]
ISBN 978-0-387-73897-0
Alberto Mantovani Istituto Clinico Humanitas and Institute of Pathology University of Milan 56 Via Manzoni Rozzano, Milano 20089, Italy [email protected]
e-ISBN 978-0-387-73898-7
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Introduction
Cancers share a restricted set of characteristics crucial to the tumor phenotype: proliferation in the absence of external growth stimuli, avoidance of apoptosis and no limits to replication, escape from external growth-suppressive forces and the immune response,
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