Technical Aspects of Toxicological Immunohistochemistry System Speci
This volume examines immunohistochemical methods for investigating the toxicologic pathology of rodent and other animal tissues. Eleven comprehensive chapters provide pathologists and researchers in various sub-disciplines of toxicology with an
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hnical Aspects of Toxicological Immunohistochemistry System Specific Biomarkers
Technical Aspects of Toxicological Immunohistochemistry
Syed A. Aziz • Rekha Mehta Editors
Technical Aspects of Toxicological Immunohistochemistry System Specific Biomarkers
Editors Syed A. Aziz Regulatory Toxicology Research Division Food Directorate Health Products and Food Branch Health Canada Ottawa, ON, Canada
Rekha Mehta Regulatory Toxicology Research Division Food Directorate Health Products and Food Branch Health Canada Ottawa, ON, Canada
Department of Pathology University of Ottawa Ottawa, ON, Canada
ISBN 978-1-4939-1515-6 ISBN 978-1-4939-1516-3 DOI 10.1007/978-1-4939-1516-3
(eBook)
Library of Congress Control Number: 2015960189 Springer New York Heidelberg Dordrecht London © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com)
Preface
Immunohistochemistry and immunocytochemistry continue to play a critical role in cell and tissue biology and diagnostic pathology. The methodologies facilitate accurate analysis of the biochemistry of cells and tissues in relation to their morphological organization. In experimental toxicological pathology in particular, enhanced immunohistochemical techniques have evolved from a concept to a core tool over the past three decades. As additional procedures to the traditional histopathology, these techniques provide for the visualization of specific features in cells and tissues such as DNA adducts, proliferating cells, dying cells, stem cells, cell cycle markers, precancerous cells, hormone receptors, brain cell-specific receptors, and oncogenes, thus leading to a greater precision in the diagnosis of alterations in cells, tissues, and organs resulting from exposure to xenobiotics and dietary constituents. The two books in this series have been made possible by contributions fro
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