Temporal changes in perihematomal apparent diffusion coefficient values during the transition from acute to subacute pha
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DIAGNOSTIC NEURORADIOLOGY
Temporal changes in perihematomal apparent diffusion coefficient values during the transition from acute to subacute phases in patients with spontaneous intracerebral hemorrhage Enrico Fainardi & Massimo Borrelli & Andrea Saletti & Silvio Sarubbo & Gloria Roversi & Andrea Bernardoni & Francesco Latini & Cristiano Azzini & Luca Borgatti & Alessandro De Vito & Michele Cavallo & Stefano Ceruti & Arturo Chieregato
Received: 8 June 2012 / Accepted: 7 September 2012 / Published online: 18 September 2012 # Springer-Verlag 2012
Abstract Introduction Diffusion-weighted imaging (DWI) studies focusing on apparent diffusion coefficient (ADC) abnormalities have provided conflicting results about the nature and fate of perihematomal edema. Methods We investigated 35 patients with supratentorial spontaneous intracerebral hemorrhage (SICH) by using DWI scanning obtained at 48 h and 7 days after symptom onset. Regional ADC (rADC) values were measured in three manually outlined regions of interest: (1) the perihematomal hyperintense area, (2) 1 cm of normal appearing brain tissue surrounding the perilesional hyperintense rim, and (3) a mirror area, including the clot and the perihematomal region, located in the contralateral hemisphere. Results rADC mean levels were lower at 7 days than at 48 h in each ROI (p
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