Tetrahydroisoquinoline derivatives: a new perspective on monoaminergic dysfunction in children with ADHD?
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BioMed Central
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Tetrahydroisoquinoline derivatives: a new perspective on monoaminergic dysfunction in children with ADHD? Veit Roessner*1, Susanne Walitza2, Franz Riederer3, Regina Hünnerkopf2, Aribert Rothenberger1, Manfred Gerlach2 and Andreas Moser4 Address: 1Department of Child and Adolescent Psychiatry, University of Goettingen, Goettingen, Germany, 2Department of Child and Adolescent Psychiatry, University of Wuerzburg, Wuerzburg, Germany, 3Department of Clinical Neurology, University of Vienna, Vienna, Austria and 4Department of Neurology, University of Lubeck, Lubeck, Germany Email: Veit Roessner* - [email protected]; Susanne Walitza - [email protected]; Franz Riederer - [email protected]; Regina Hünnerkopf - [email protected]; Aribert Rothenberger - [email protected]; Manfred Gerlach - [email protected]; Andreas Moser - [email protected] * Corresponding author
Published: 10 December 2007 Behavioral and Brain Functions 2007, 3:64
doi:10.1186/1744-9081-3-64
Received: 15 June 2007 Accepted: 10 December 2007
This article is available from: http://www.behavioralandbrainfunctions.com/content/3/1/64 © 2007 Roessner et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background: The dopamine-derived tetrahydroisoquinolines (TIQ) synthesized endogeneously from aldehydes and catecholamines have shown to modulate neurotransmission, central metabolism and motor activity. Converging evidence has implicated abnormalities of the dopamine metabolism to the pathophysiology of Attention-Deficit/Hyperactivity Disorder (ADHD). Therefore, four TIQ derivatives involved in central dopamine metabolism (salsolinol, N-methylsalsolinol, norsalsolinol, N-methyl-norsalsolinol) have been analyzed for the first time in children and adolescents with ADHD and healthy controls. Methods: 42 children and adolescents with ADHD and 24 controls from three sites participated in this pilot study. Free and bound amounts of salsolinol, N-methyl-salsolinol, norsalsolinol, Nmethyl-norsalsolinol have been analyzed in urine. Results: In the ADHD group, free and total amounts of the four TIQ derivatives in urine were significantly higher compared to urine levels of healthy controls. For N-methyl-salsolinolfree, most of the ADHD patients were identified correctly with a sensitivity of 92.5% (specificity 94.4%). Conclusion: Urine levels of salsolinol, N-methyl-salsolinol, norsalsolinol and N-methylnorsalsolinol are elevated in children and adolescents with ADHD and point to a new perspective on catecholaminergic dysfunction in ADHD. However, replication and extension of this pilot study would progress this innovative and promising field.
Background Attention-Deficit/Hyperactivity Disorder (ADHD) is a common worldwid
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