The A-SACT (Achievement in Singapore of Cholesterol Targets) Study in Patients with Coronary Heart Disease
- PDF / 140,907 Bytes
- 9 Pages / 592.44 x 751.18 pts Page_size
- 8 Downloads / 219 Views
ORIGINAL RESEARCH ARTICLE
© 2006 Adis Data Information BV. All rights reserved.
The A-SACT (Achievement in Singapore of Cholesterol Targets) Study in Patients with Coronary Heart Disease Kheng-Thye Ho,1 Khong-Whee Chin,2 Kheng-Siang Ng,1 Evo Alemao,3 Srinivasan Rajagopalan4 and Don Yin3 1 2 3 4
Tan Tock Seng Hospital, Singapore, Republic of Singapore Merck Research Laboratories, Rahway, New Jersey, USA Outcomes Research, Merck and Co., Inc., Whitehouse Station, New Jersey, USA Med Data Analytics Inc., Williamsville, New York, USA
Abstract
Background: Cardiovascular disease remains a leading cause of death worldwide, with hypercholesterolemia being a major risk factor. Evidence-based consensus guidelines have recommended consideration of increasingly stringent cholesterol-lowering goals, yet most patients do not meet these targets. Coronary heart disease (CHD) event and mortality rates and mean serum cholesterol levels have declined in Singapore in recent years; however, certain groups remain at elevated risk. Objective: To determine (i) proportions of patients with CHD in Singapore who achieved goals for serum low-density lipoprotein-cholesterol (LDL-C); and (ii) factors influencing goal attainment. Methods: A historical cohort study was conducted using records from the Singapore Cardiac Databank, a national registry of CHD patients. Serum LDL-C goal attainment was assessed in 5174 survivors of acute myocardial infarction or coronary revascularization (i.e. coronary artery bypass graft surgery or percutaneous coronary interventions), of whom 3811 (73.7%) were at very high risk. Results: At baseline, the mean patient age was 60.3 years, mean serum value of total cholesterol was 228 mg/dL, and mean LDL-C was 163 mg/dL. Of all CHD patients, approximately 70% did not achieve a serum LDL-C target of
Data Loading...
