The association between genetic variants in the genes for cytochrome P450 B1 and ATP-binding cassette transporter genes
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ORIGINAL ARTICLE
The association between genetic variants in the genes for cytochrome P450 B1 and ATP‑binding cassette transporter genes and breast cancer risk Soodabeh ShahidSales1 · Mehrane Mehramiz2 · Davood Radmanesh1 · Azam Rastgar‑Moghadam2 · Seyed Mahdi Hassanian2 · Majid Khazaei2 · Hamideh Ghazizade3 · Gordon A. Ferns4 · Amir Avan2,3 Received: 2 November 2019 / Accepted: 18 July 2020 © Springer Nature B.V. 2020
Abstract Breast cancer is among the most common malignancies in women. Recent studies have shown that polymorphisms in genes involved in the metabolism and transport of anticancer drugs are associated with outcomes of several malignancies, e.g., breast cancer. In this study we evaluate whether CYP1B1/rs1056836 and ABCB1/rs2032582 gene variants are associated with breast cancer. Eighty eight cases and 200 controls, were genotyped for polymorphisms of the CYP1B1 and ABCB1 genes using Taqman®-based methods. Logistic regression was also used to test the associations between breast cancer risk and the various genotypes involved. The GG genotype of rs2032582 locus had a frequency of 43.5% with 0.38 MAF; while the GT and TT genotypes in the control group were 40% and 16.5%, respectively. The GG, GT and TT genotype frequencies in the patients with breast cancer were 45.5%, 12.5% and 26.1%, respectively. An association was observed between the TT genotype of ABCB1/rs2032582 locus and a larger breast cancer tumor size (P
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