The association between periconceptional folic acid supplementation and the risk of preterm birth: a population-based re
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ORIGINAL CONTRIBUTION
The association between periconceptional folic acid supplementation and the risk of preterm birth: a population‑based retrospective cohort study of 200,000 women in China Yu Wu1 · Yanling Yuan2 · Cai Kong2 · Qiuyue Ma1 · Hanfeng Ye2 · Wenzhan Jing1 · Jue Liu1 · Min Liu1 Received: 8 May 2020 / Accepted: 6 October 2020 © The Author(s) 2020
Abstract Purpose The aim of this study was to examine the association between periconceptional folic acid (FA) supplementation and risk of preterm birth. Methods We conducted a retrospective cohort study in women aged 18–49 who participated in the NFPHEP from 2010 to 2018, and had a singleton livebirth in 129 counties in southwest China. Participants were divided into four groups according to the time period starting FA use: no use, after the last menstrual period, at least 1–2 months before the last menstrual period, at least 3 months before the last menstrual period. The outcomes were preterm birth (gestation
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