The Association Between Periodontitis and Cardiovascular Disease: an Update
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CORONARY HEART DISEASE (S. VIRANI AND S. NADERI, SECTION EDITOR)
The Association Between Periodontitis and Cardiovascular Disease: an Update Sahar Naderi 1 & Anwar T. Merchant 2
# Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose of the Review The purpose of this review is to provide an update on the data regarding periodontitis and its association with cardiovascular disease (CVD), as well as a closer look at the connection between periodontitis and valvular heart disease. Recent Findings The body of literature that demonstrates an association between periodontitis and CVD is growing, and there is increasing evidence that periodontal disease (PD) can have negative cardiovascular effects. Far less data is available for the management of periodontitis specifically in those with valvular heart disease. However, recent studies suggest that routine preoperative dental evaluation practices may not be necessary in all patients and, similar to changes in antibiotic prophylaxis, may only be indicated for a select group of individuals. Summary There is a strong association between PD and CVD, although a causal relationship is yet to be elucidated. Further data is needed in this regard, as well as in determining the appropriate management of PD in those with valvular heart disease. Keywords Periodontitis . Periodontal disease . Cardiovascular disease . Endocarditis
Introduction Periodontitis is a chronic inflammatory condition caused by bacterial destruction of the dental bone and connective tissue [1]. An estimated half of the US population has some degree of periodontitis, with 5–15% of adults with a severe form of the disease [2]. These estimates are likely even higher in developing countries. Given increasing data suggesting that chronic inflammatory conditions can increase the risk of cardiovascular disease (CVD) [3], attention has been turned to periodontitis and its potential link to CVD. While a possible association between periodontitis and atherosclerotic CVD has been more recently recognized, the link between dental procedures and bacteremia, and the implications on valvular heart disease, dates as far back as the early 1900s [4]. This This article is part of the Topical Collection on Coronary Heart Disease * Sahar Naderi [email protected] 1
Division of Cardiology, Kaiser Permanente, 2238 Geary Boulevard 8th Floor, San Francisco, CA 94115, USA
2
Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA
ultimately led to guidelines for antibiotic prophylaxis prior to dental procedures and was the impetus for dental evaluation or “dental clearance” prior to heart valve surgery [4]. In this review, we will discuss focused updates in the relationship between periodontitis and CVD that expands upon a prior publication on the topic in this journal [5], including an evaluation of the data surrounding dental evaluation prior to cardiovascular surgery.
Relationship Between Periodontal Disease, Inflammation, and
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