The Association of Major Depressive Disorder with Activation of NLRP3 Inflammasome, Lipid Peroxidation, and Total Antiox
- PDF / 297,386 Bytes
- 6 Pages / 595.276 x 790.866 pts Page_size
- 5 Downloads / 232 Views
The Association of Major Depressive Disorder with Activation of NLRP3 Inflammasome, Lipid Peroxidation, and Total Antioxidant Capacity Abdolghader Taene 1 & Ghazaleh Khalili-Tanha 2 & Aliakbar Esmaeili 3 & Leila Mobasheri 1 & Omid Kooshkaki 1 & Somaieh Jafari 4 & Alireza Shokouhifar 4 & Gholamreza Anani Sarab 2 Received: 21 January 2019 / Accepted: 27 August 2019 # Springer Science+Business Media, LLC, part of Springer Nature 2019
Abstract Increasing number of studies indicates that chronic inflammation and oxidative stress play an essential role in pathophysiology and some symptoms of major depressive disorder (MDD). In the present study, the inflammasome activity and oxidative stress status in untreated and antidepressant-treated MDD patients were compared to the healthy group. Blood samples were taken from 20 MDD patients receiving treatment, 20 first-episode MDD patients not receiving treatment, and 20 healthy controls. The expression level of NLRP3 and caspase-1 was measured by real-time PCR and the serum TAC and MDA were examined in the patients and the control groups. The results showed that the mRNA level of NLRP3 and caspase-1 genes was significantly elevated in MDD groups compared with that in the healthy volunteers (P < 0.005). The expression level of NLRP3 and caspase-1 has slightly decreased in the treated group compared with that in the untreated one, but it was not a meaningful decrease. Moreover, the serum MDA was significantly higher and TAC statistically was lower in untreated MDD patients compared with those in the healthy control group (P = 0.001, P = 0.001). It can be concluded that NLRP3 inflammasome is upregulated in MDD patients. Statistically significant reduction in the level of TAC along with increased lipid peroxidation was detectable in MDD patient’s plasma. In contrast, there was no significant difference between the treated and non-treated groups in terms of oxidative stress (P = 0.6, P = 0.1). Our results suggested that inflammasome signaling pathway is a therapeutic potential for MDD. Keywords Major depressive disorder . Total antioxidant activity . Lipid peroxidation (LPO) . NLRP3 inflammasome
Introduction Depression is a common, expensive, and devastating psychiatric disorders (Miller and Raison 2016). Approximately 16% of men and 25% of women experience depression during their lifetime course (Kessler et al. 2010). In the previous studies, it was estimated that by 2020, depression, after heart disease, will be the second illness that will inflict high costs on * Gholamreza Anani Sarab [email protected] 1
Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran
2
Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran
3
Psychiatry and Behavioral Science Research Center, Birjand University of Medical Sciences, Birjand, Iran
4
Molecular Medicine Department & Genomic Research Center, Birjand University of Medical Sciences, Birjand, Iran
societies and affect more than 10% of the general population (Alcocer-Gómez e
Data Loading...
