The Birth of Malignancy: Embryogenesis and Melanoma
Embryonic development involves high levels of proliferation, migration, and differentiation to form all the tissues and organs of an organism. Under normal circumstances, cell–cell signaling in an embryo is coordinated both temporally and spatially to all
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Melanoma Development Molecular Biology, Genetics and Clinical Application Second Edition
Melanoma Development
Anja K. Bosserhoff Editor
Melanoma Development Molecular Biology, Genetics and Clinical Application Second Edition
Editor Anja K. Bosserhoff Institute for Biochemistry Erlangen Germany
ISBN 978-3-319-41317-4 ISBN 978-3-319-41319-8 (eBook) DOI 10.1007/978-3-319-41319-8 Library of Congress Control Number: 2016959044 © Springer International Publishing AG 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
This book, Melanoma Development: Molecular Biology, Genetics and Clinical Application, in its second edition provides a comprehensive insight into the molecular changes of malignant melanoma and implications for therapeutic approaches. In this updated version, all chapters were revised and important new developments and findings of the recent 4 years were added. The recent clinical success in treating melanoma by inhibitors to mutated BRAF or activated MEK or by stimulating the immune system by checkpoint blockage is very encouraging. After years without strong effects of therapeutical attempts, there is hope that melanoma is curable or at least can be shifted into chronic disease. Of course, more research is strongly needed for a comprehensive understanding of the molecular processes leading to melanoma and of ways to therapy resistance. Nevertheless, the first steps are made with possibilities leading to significantly prolonged survival of the patients with metastasized melanoma. This is a highly inspiring and promising development which should further boost melanoma research. I am again very grateful to all the authors for their interesting, forward-looking contributions and for their support of this book project. I feel that t
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