The clinical presentation, treatment and outcome of serologically confirmed paediatric Lyme disease in the Republic of I
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ORIGINAL ARTICLE
The clinical presentation, treatment and outcome of serologically confirmed paediatric Lyme disease in the Republic of Ireland over a 5-year period: a retrospective cohort study Karina M. Forde 1,2 & Joanne O’Gorman 3 & Patrick J. Gavin 2 & Matthew S. Dryden 4 & Deirbhile Keady 5 & Belinda Hanahoe 5 & Colm McDonnell 6 & Lorraine Power 6 & Bartley Cryan 7 & James Sweeney 8 & Karl F. Conyard 9 & Michael J. O’Grady 1,10 Received: 15 April 2020 / Accepted: 1 October 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Lyme disease (LD) is the most common tick-borne illness in Europe. Population-based studies in European children are few. This study aimed to assess the incidence, clinical presentation, treatment and outcome of serologically confirmed paediatric LD in the Republic of Ireland over a 5-year period. A retrospective review of records from accredited laboratories performing Borrelia burgdorferi serological testing was undertaken. Proformas were distributed to clinicians of children and adolescents with positive Lyme serology. Data were requested regarding clinical presentation, treatment and outcome. Updated NICE guidelines were used to classify clinical cases. Serology testing for B. burgdorferi was performed on 2908 samples. Sixty-three (2.2%) children were two-tier positive, generating a crude annual incidence rate of 1.15/100,000. Proformas were returned for 55 (87%) and 47 met clinical and laboratory criteria for LD. Twenty-seven (57%) presented with non-focal symptoms (erythema migrans and/or influenza-like symptoms), and 20 (43%) with focal symptoms (cranial nerve involvement, 11; CNS involvement, 8; arthritis, 1). Median age at presentation was 8.2 (2.5–17.9) years. Seventeen (36%) acquired LD overseas. Twenty-five (83%) of the remaining 30 children acquired infection in the West/Northwest of Ireland. Full resolution of symptoms was reported in 97% of those with available data. Serologically confirmed LD in children is relatively rare in the Republic of Ireland. Ninety-eight percent of children tested were seronegative. Of the seropositive cases, 40% could have been diagnosed based on clinical findings alone. Neurological presentations (40%) were common. Full resolution of symptoms occurred in almost all (97%) where data were available. Keywords Lyme disease . Erythema migrans . Neuroborreliosis . Borrelia burgdorferi
* Karina M. Forde [email protected] 1
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Department of Paediatrics, Regional Hospital Mullingar, Westmeath, Ireland Department of Paediatric Infectious Diseases, Children’s Health Ireland, Crumlin and Temple St., Dublin, Ireland National Virus Reference Laboratory, University College Dublin, Belfield, Dublin 4, Ireland Rare and Imported Pathogens Laboratory, Public Health England, Porton Down, Salisbury, UK
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Department of Medical Microbiology, Galway University Hospital, Galway, Ireland
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Department of Medical Microbiology, University Hospital Limerick, Limerick, Ireland
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Department of Medical Microbiology, Cork University Hosp
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