The Correlation Between RDW, MPV and Weight Indices After Metabolic Surgery in Patients with Obesity and DM/IGR: Follow-

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ORIGINAL RESEARCH

The Correlation Between RDW, MPV and Weight Indices After Metabolic Surgery in Patients with Obesity and DM/IGR: Follow-Up Observation at 12 Months Li Zhou . Shibo Lin . Fan Zhang . Yizhe Ma . Zhenzhen Fu . Yingyun Gong . Dandan Hu . Shuai Ma . Xuan Ye . Leihang Qian . Xiaomei Geng . Ningli Yang . Hui Liang . Hongwen Zhou Received: June 19, 2020 Ó The Author(s) 2020

ABSTRACT Introduction: Red blood cell distribution width (RDW) and mean platelet volume (MPV) are both new biomarkers for the prognosis of many diseases. This study aimed to observe the predictive values of RDW and MPV for weight loss Li Zhou and Shibo Lin contributed equally to this work. Hongwen Zhou is the principal corresponding author, and Hui Liang is the co-corresponding author.

Digital Features To view digital features for this article go to https://doi.org/10.6084/m9.figshare.12721874. L. Zhou  F. Zhang  Y. Ma  Z. Fu  Y. Gong  D. Hu  S. Ma  X. Ye  L. Qian  X. Geng  N. Yang  H. Liang (&)  H. Zhou (&) Department of Endocrinology and Metabolism, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu, China e-mail: [email protected] H. Zhou e-mail: [email protected] L. Zhou Department of Endocrinology and Metabolism, The Affiliated Huai’an No.1 People’s Hospital of Nanjing Medical University, 1 Huanghe West Road, Huai’an 223300, Jiangsu, China S. Lin Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu, China

after different metabolic surgeries in patients with obesity and abnormal glucose metabolism [diabetes mellitus or impaired glucose regulation (DM/IGR)]. Methods: We retrospectively analyzed the body weight (BW), body mass index (BMI) and blood routine index of 98 patients with obesity and DM/IGR who underwent Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG). Results: Levels of RDW and MPV in both groups were significantly higher than before 1 month after surgery and then gradually decreased. Twelve months after surgery, the RDW level in the RYGB group was significantly lower than that before surgery. In the RYGB group, the RDW level of patients in the high-level percentage weight loss (%BW) (C 31.90) at 6 and 12 months after surgery decreased significantly compared to those in the corresponding low level. %BW and change in BW and BMI (DBW and DBMI) at 6 and 12 months after surgery in the high-level RDW (C 12.90) before surgery were significantly higher than those in the low level in the RYGB group. No significant difference in weight index was found in the high and low levels of the MPV before surgery in either group at other follow-up time points. Conclusions: Preoperative baseline RDW and postoperative RDW levels can preliminarily predict the effect of different metabolic surgeries in patients with obesity and DM/IGR. Keywords: Diabetes mellitus; Impaired glucose regulation; Mean platelet volume; Metabolic

Diabetes Ther

surgery; Obesity; Red blood cell di