The Effect of Iodine-Containing Vitamin Supplementation During Pregnancy on Thyroid Function in Late Pregnancy and Postp
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The Effect of Iodine-Containing Vitamin Supplementation During Pregnancy on Thyroid Function in Late Pregnancy and Postpartum Depression in an Iodine-Sufficient Area Zixiao Wang 1 & Chenyang Li 2 & Ying Teng 3 & Yunping Guan 2 Haixia Guan 1
&
Li Zhang 2 & Xi Jia 2 & Dandan Cui 2 & Jing Li 2 &
Received: 4 October 2019 / Accepted: 1 January 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract The purpose of this study was to investigate the effect of iodine supplementation during pregnancy on thyroid function and also its effect on postpartum depression in an iodine-sufficient area. Healthy pregnant women were divided into three groups: group A (vitamin iodine–150) receiving vitamin containing 150 μg iodine, group B (vitamin iodine–0) receiving vitamin without iodine, and group C (no vitamin) receiving no vitamin. General information was collected by questionnaire and thyroid function was determined in the third trimester of pregnancy. Depression was assessed 1 month postpartum by the Edinburgh postnatal depression scale (EPDS). The results showed that there was no significant difference in thyroid-stimulating hormone (TSH) level among the three groups (P > 0.05). FT4 concentration was significantly lower in group A (n = 234: 10.68 pmol/L) than in group B (n = 220: 11.47 pmol/L) and group C (n = 195: 11.64 pmol/L) (P < 0.05), However, it was still within the normal range. EPDS scores obtained from group B (3.50) and group C (3.00) were similar but markedly lower than group A (5.00) (P < 0.05). Despite the difference in the EPDS score, the prevalence of postpartum depression was not significantly different among the three groups. In conclusion, 150 μg/day iodine supplementation for pregnant women in areas with adequate iodine had little effect on thyroid function in the third trimester, and serum FT4 level could not be increased. Iodine supplementation during pregnancy also had no significant effect on postpartum depression. Keywords Iodine . Pregnancy . Postpartum depression . Thyroid
Introduction Iodine is an important microelement in the human body and the main element for the synthesis of the thyroid hormones.
Iodine accounts for 65% and 59% of the weight of T4 and T3, respectively [1]. Iodine nutrition is also closely related to maternal thyroid function in pregnant women. Thus, reduced thyroid hormone production due to iodine deficiency may
Zixiao Wang and Chenyang Li contributed equally to this work. * Haixia Guan [email protected]
Dandan Cui [email protected]
Zixiao Wang [email protected] Chenyang Li [email protected]
Jing Li [email protected] 1
Department of Endocrinology and Metabolism and Institute of Endocrinology, The First Hospital of China Medical University, 155 Nanjing Bei Street, Shenyang 110001, Liaoning, People’s Republic of China
2
Department of Gynaecology and Obstetrics, Shenyang Maternity and Child Health Hospital, Shenyang 110000, Liaoning, People’s Republic of China
3
Department of Gynaecology and Obstetrics, Shenyang Fifth People Hosp
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