The effects of radioiodine therapy on parathyroid function among patients with papillary thyroid cancer: a retrospective
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ORIGINAL ARTICLE
The effects of radioiodine therapy on parathyroid function among patients with papillary thyroid cancer: a retrospective cohort study Yuan Fei
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Yuxuan Qiu1 Zhichao Xing1 Wanjun Zhao1 Anping Su1 Jingqiang Zhu1 ●
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Received: 11 April 2020 / Accepted: 18 July 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose To explore the effects of initial radioiodine therapy on parathyroid function among postoperative papillary thyroid cancer (PTC) patients. Methods Postoperative PTC patients who were admitted in our department from April 2018 to April 2019 were recruited. Patients were divided into two groups: Group A, who underwent surgery and initial radioiodine therapy in our hospital, and Group B, who did not receive radioiodine therapy after surgery. The levels of serum calcium, magnesium, phosphorus, parathyroid hormone (PTH), and 25 hydroxyvitamin D3 were collected. Data were analyzed by SPSS 25.0. Results A total of 252 patients were included. Between the two groups, no significant difference of PTH in 6th, 9th, and 12th month was found during postoperative follow-up (p = 0.493, p = 0.202, p = 0.814). No significant difference of PTH was found after stratifying Group A according to 131I dosage (p = 0.751 for 6th month after operation, p = 0.130 for 9th month after operation, p = 0.683 for 12th month after operation), interval time between surgery and radioiodine therapy (p = 0.522 for 3rd day after 131I therapy, p = 0.184 for 9th month after operation, p = 0.311 for 12th month after operation), and ratio of parathyroid autotransplantation (p = 0.545 for 3rd day after 131I therapy, p = 0.485 for 6th month after operation, p = 0.201 for 9th month after operation, p = 0.146 for 12th month after operation). Conclusions Initial radioiodine therapy following PTC surgery had no significant adverse effect on parathyroid function in the short term. However, physicians should inform patients of possible risks of abnormal parathyroid function prior to RAI therapy, and parathyroid function was periodically reviewed after RAI therapy. keywords Radioiodine Papillary thyroid cancer Parathyroid hormone ●
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Introduction The incidence of thyroid carcinoma has increased dramatically in the last decades [1]. Papillary thyroid cancer (PTC) is the major histopathological type among thyroid malignancy [2, 3]. At present, the treatment of PTC includes
Supplementary information The online version of this article (https:// doi.org/10.1007/s12020-020-02429-8) contains supplementary material, which is available to authorized users. * Anping Su [email protected] * Jingqiang Zhu [email protected] 1
Department of Thyroid & Parathyroid Surgery, West China Hospital, Sichuan University, NO. 37 Guo Xue Xiang, 610041 Chengdu, Sichuan, PR China
conservative treatment, operation, thyrotropin suppression therapy, radioactive iodine (RAI) therapy (or 131I therapy), external radiation, and chemotherapy [4]. In 1938, Glenn Seaborg et al. discovered 131I
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