The Effects of Synbiotic Supplementation on Pregnancy Outcomes in Gestational Diabetes
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The Effects of Synbiotic Supplementation on Pregnancy Outcomes in Gestational Diabetes Maryam Karamali 1 & Nabiollah Nasiri 1 & Naemeh Taghavi Shavazi 1 & Mehri Jamilian 2 & Fereshteh Bahmani 3 & Maryam Tajabadi-Ebrahimi 4 & Zatollah Asemi 3
# Springer Science+Business Media, LLC 2017
Abstract Synbiotics are known to exert multiple beneficial effects, including anti-inflammatory and antioxidative actions. This study was designed to evaluate the effects of synbiotic administration on biomarkers of inflammation, oxidative stress, and pregnancy outcomes among gestational diabetic (GDM) women. This randomized, double-blind, placebocontrolled clinical trial was carried out among 60 subjects with GDM who were not on oral hypoglycemic agents. Patients were randomly assigned to consume either one synbiotic capsule containing Lactobacillus acidophilus strain T16 (IBRCM10785), L. casei strain T2 (IBRC-M10783), and Bifidobacterium bifidum strain T1 (IBRC-M10771) (2 × 109 CFU/g each) plus 800 mg inulin (HPX) (n = 30) or placebo (n = 30) for 6 weeks. Compared with the placebo, synbiotic supplementation significantly decreased serum high-sensitivity C-reactive protein (hs-CRP) (− 1.9 ± 4.2 vs. +1.1 ± 3.5 mg/L, P = 0.004), plasma malondialdehyde (MDA) (− 0.1 ± 0.6 vs. + 0.3 ± 0.7 μmol/L, P = 0.02), and significantly increased total antioxidant capacity (TAC) (+ 70.1 ± 130.9 vs. − 19.7 ± 124.6 mmol/L, P = 0.009) and total glutathione (GSH) levels (+ 28.7 ± 61.5 vs. − 14.9 ± 85.3 μmol/L, P = 0.02). Supplementation with
* Zatollah Asemi [email protected] 1
Department of Gynecology and Obstetrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
2
Endocrinology and Metabolism Research Center, Arak University of Medical Sciences, Arak, Iran
3
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R, Iran
4
Faculty member of Science department, science faculty, Islamic Azad University, Tehran Central branch, Tehran, Iran
synbiotic had a significant decrease in cesarean section rate (1 6.7 vs. 40 .0% , P = 0.0 4), l ower inc i den ce of hyperbilirubinemic newborns (3.3 vs. 30.0%, P = 0.006), and newborns’ hospitalization (3.3 vs. 30.0%, P = 0.006) compared with the placebo. Synbiotic supplementation did not affect plasma nitric oxide (NO) levels and other pregnancy outcomes. Overall, synbiotic supplementation among GDM women for 6 weeks had beneficial effects on serum hs-CRP, plasma TAC, GSH, and MDA; cesarean section; incidence of newborn’s hyperbilirubinemia; and newborns’ hospitalization but did not affect plasma NO levels and other pregnancy outcomes. http://www.irct.ir: www.irct.ir: IRCT201704205623N108 Keywords Synbiotic supplementation . Gestational diabetes . Pregnant women
Introduction Gestational diabetes (GDM) is defined as hyperglycemia, insulin resistance, and carbohydrate intolerance with the onset or first recognition during pregnancy [1]. The prevalence of GDM is 6–20% of pregnant women, and its prevalence is increasing in pa
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