The efficacy of the submucosal injection of lidocaine during endoscopic submucosal dissection for colorectal neoplasms:
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and Other Interventional Techniques
The efficacy of the submucosal injection of lidocaine during endoscopic submucosal dissection for colorectal neoplasms: a multicenter randomized controlled study Masami Ijiri1 · Takahiro Sasaki1 · Mikihiro Fujiya1 · Takuya Iwama1 · Yuki Murakami1 · Keitaro Takahashi1 · Kazuyuki Tanaka3 · Katsuyoshi Ando1 · Nobuhiro Ueno1 · Shin Kashima1 · Kentaro Moriichi1 · Hiroki Tanabe1 · Yusuke Saito2 · Toshikatsu Okumura1 Received: 16 April 2020 / Accepted: 16 September 2020 © The Author(s) 2020
Abstract Background Endoscopic submucosal dissection (ESD) is currently a common procedure although it requires a long procedural time. We conducted a prospective study to determine the efficacy and safety of lidocaine injection for shortening the procedural time and relieving bowel peristalsis during ESD. Methods A multicenter randomized controlled study was conducted in three hospitals. Ninety-one patients who underwent colorectal ESD were enrolled. Patients were randomly divided into two groups using the envelope method: the lidocaine group and saline group. The primary endpoint was the procedural time, and the secondary endpoints were the procedural time in each part of the colon and the grade of bowel peristalsis and the incidence and amounts of antispasmodic drugs use and adverse events. Results The patients’ demographics were not markedly different between the two groups. The mean procedural time in the lidocaine group was not markedly different from that in the saline group. In contrast, at the proximal site, the procedural time in the lidocaine group (57 min) was significantly shorter in the saline group (80 min). The grade of bowel peristalsis in the lidocaine group (0.67) was significantly lower than in the saline group (1.17). Antispasmodic drug use was significantly rarer in the lidocaine group than in the saline group. The incidence of adverse events was not markedly different between the two groups. Conclusions Local lidocaine injection is a feasible option for preventing bowel peristalsis, particularly in the proximal colon, leading to a reduced procedural time for ESD and decreased antispasmodic drug use. University Hospital Medical Information Network Center (UMIN number: 000022843). Endoscopic submucosal dissection (ESD) is a common procedure for the treatment of colorectal T1 cancer, particularly Masami Ijiri, Takahiro Sasaki, and Mikihiro Fujiya contributed equally to this study. * Mikihiro Fujiya fjym@asahikawa‑med.ac.jp 1
Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, 2‑1‑1‑1, Midorigaoka, Asahikawa, Hokkaido 078‑8510, Japan
2
Department of Gastroenterology, Asahikawa City Hospital, Asahikawa, Hokkaido, Japan
3
Department of Gastroenterology, Asahikawa Kosei Hospital, Asahikawa, Hokkaido, Japan
large lesions. However, ESD carries a high risk of perforation and requires a longer procedural time than other endoscopic procedures, including polypectomy and endoscopic mucosal resection [1]. Submucosal
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