The Efficiency of a Urotensin II Antagonist in an Experimental Lung Fibrosis Model
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The Efficiency of a Urotensin II Antagonist in an Experimental Lung Fibrosis Model Ahmet Mesut Onat,1 Ibrahim Halil Turkbeyler,2 Yavuz Pehlivan,1,3,8 Tuncer Demir,4 Davut Sinan Kaplan,4 Seyithan Taysi,5 Ali Osman Ceribasi,6 Ediz Tutar,7 and Bunyamin Kisacik1
Abstract—Pulmonary fibrosis is a chronic disease. Urotensin II (U-II) is a new peptide with angiogenic and profibrotic features. Therefore, we aim to evaluate the antagonism of U-II with palosuran in an animal model and plan to measure U-II, endothelin-1 (ET-1), and transforming growth factor-β1 (TGF-β1) and their association with lung fibrosis. Thirty Wistar male rats were used in the study and were divided into three groups: group 1, control; group 2, bleomycin-induced lung fibrosis group; and group 3, bleomycin-induced lung fibrosis with treatment palosuran group. U-II level (nanograms per milliliter) was 2.957±0.159 in group1, 3.188±0.122 in group 2, and 2.970±0.165 in group 3 (p=0.002). The ET-1 level (picograms per milliliter) was 4.486±0.376 in group 1, 9.086± 1.850 in group 2, and 4.486±0.376 in group 3 (p
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