The expression level of COX7C associates with venous thromboembolism in colon cancer patients
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ORIGINAL ARTICLE
The expression level of COX7C associates with venous thromboembolism in colon cancer patients Biyu Wu1 · Shurong Chen2 · Lihong Zhuang3 · Jingyang Zeng4 Received: 19 May 2020 / Accepted: 2 July 2020 © Springer Nature Switzerland AG 2020
Abstract Venous thromboembolism (VTE) is a common complication of colon cancer. In the present study, we aimed to explore the association of the oncogene COX7C to VTE in colon cancer patients. Samples from 580 patients were examined histologically for VTE and pathological characteristic of cancer. Gene mutation and expression analysis were performed using polymerase chain reaction-based assays to evaluate genes related to VTE, including COX7C. Univariate analysis between clinical pathological factors and VTE was conducted. Logistic regression analysis was performed for the prediction of VTE by pathological factors and gene expressions. Among patients investigated, a total of 56 patients had VTE. COX7C had a significant correlation with VTE (p 0.05), only COX7C expression demonstrated significance in its ability to predict VTE. Here, we show that COX7C upregulation strongly correlates with VTE in colon cancer, which implicates its role as a biomarker and therapeutic target of VTE in colon cancer. Keywords Colon cancer · Venous thromboembolism · COX7C
Introduction Venous thromboembolism (VTE) is one of the most frequently occurring and high-risk complications of tumors, with an incidence rate of 4–20% [1]. VTE severely deteriorates the quality of life of patients, and it is also one of the leading causes of death among tumor patients. The incidence rate of VTE in colon cancer patients is as high as 15% [2], * Jingyang Zeng [email protected] 1
Department of Nursing, Quanzhou First Hospital Affiliated To Fujian Medical University, No.250 East Street, Licheng District, Quanzhou 362000, Fujian, China
2
Department of Geriatric, Quanzhou First Hospital Affiliated To Fujian Medical University, No.250 East Street, Licheng District, Quanzhou 362000, Fujian, China
3
Second Department of Gastrointestinal Surgery, Quanzhou First Hospital Affiliated To Fujian Medical University, No.250 East Street, Licheng District, Quanzhou 362000, Fujian, China
4
Department of Anesthesiology, Quanzhou First Hospital Affiliated To Fujian Medical University, No.250 East Street, Licheng District, Quanzhou 362000, Fujian, China
and two common sites of VTE mainly include deep vein thrombosis (DVT) and pulmonary embolism (PE). Despite the significant need for VTE prevention and treatment, there is unfortunately currently no accurate tool for the prediction of VTE in cancer patients, greatly hindering early treatment of the disease. Many studies have devoted to the development of either pathological or genetic markers of VTE to delineate risk of progression [3, 4]. It was shown that mutations in some tumor suppressor or promoter genes are closely related to the occurrence of colon cancer and VTE [5]. For example, the mutational status of the putative tumor oncogene, K
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