The Feasibility of Recruiting and Retaining Perinatal Latinas in a Biomedical Study Exploring Neuroendocrine Function an
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ORIGINAL PAPER
The Feasibility of Recruiting and Retaining Perinatal Latinas in a Biomedical Study Exploring Neuroendocrine Function and Postpartum Depression Sandraluz Lara-Cinisomo1,2 • Jasmine Plott2 • Karen Grewen2 • Samantha Meltzer-Brody2
Ó Springer Science+Business Media New York 2016
Abstract This study evaluates the feasibility of enrolling and retaining perinatal immigrant and U.S.-born Latinas in a laboratory-based study that includes the collection of biomarkers implicated in the development of postpartum depression. This prospective study followed Latinas from third trimester of pregnancy to 12 weeks postpartum. Women were enrolled during pregnancy and interviewed at 4, 8 and 12 weeks postpartum. Demographic information, depression status and breastfeeding practices were ascertained using validated Spanish- and English-measures. Blood samples were collected at the 8-week postpartum laboratory visit during infant feeding and pain testing. Feasibility was demonstrated with 85 % retention of the original 34 prenatal women enrolled in the study. The majority (88 %) of women enrolled attended the 8-week laboratory visit regardless of depression status. This is the first study to demonstrate feasibility of enrolling and retaining depressed and nondepressed perinatal immigrant and U.S.-born Latinas in biomedical research. & Sandraluz Lara-Cinisomo [email protected] Jasmine Plott [email protected] Karen Grewen [email protected] Samantha Meltzer-Brody [email protected] 1
Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, 1204 Fourth Street, Khan 2015, Champaign, IL 61820, USA
2
Department of Psychiatry, UNC School of Medicine, University of North Carolina at Chapel Hill, 101 Manning Drive, 10514 Neurosciences Hospital, Chapel Hill, NC 27599-7160, USA
Keywords Latina Feasibility Perinatal women Postpartum depression Biomedical study
Introduction Postpartum depression (PPD), a major depressive episode that occurs following delivery, is the leading medical complication among new mothers [1]. Latinas in the U.S. are disproportionately affected by PPD, with three-fold greater rate (30–43 %) than the general population (10–19 %) [2, 3]. Latinas are a critically important study population because of high fertility rates and multiple psychosocial risk factors for PPD (e.g., poverty). There is growing research showing that adverse life events (ALE), such as poverty, are risk factors for PPD [4]. Immigrant Latinas may face additional stressors, including acculturative stress (i.e., social and psychological stress that occur when adapting to a new culture) that may make them especially vulnerable to PPD [5]. A history of ALE has been associated with dysregulation of the hypothalamic–pituitary–adrenal (HPA) stress axis, the stress response system that produces adrenocorticotrophic hormone (ACTH) and cortisol (CORT) to regulate the body’s response to stress (e.g., increased ACTH and blunted CORT) [6]. Dysregulation of the HPA axis has bee
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