The fraction of sensitization among lung transplant recipients in a transplant center in Japan
- PDF / 671,798 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 55 Downloads / 183 Views
RESEARCH ARTICLE
Open Access
The fraction of sensitization among lung transplant recipients in a transplant center in Japan Sakiko Kumata1†, Takashi Hirama1,2*† , Yui Watanabe1, Hisashi Oishi1, Hiromichi Niikawa1, Miki Akiba2, Jussi Tikkanen3 and Yoshinori Okada1,2
Abstract Background: Anti-human leukocyte antigen (HLA) antibody testing was approved by the Japanese government in 2018. As such, there was no longitudinal data regarding the HLA-sensitization of lung transplant (LTX) patients in Japan. We therefore set out to measure anti-HLA antibodies from all our LTX patients during their annual follow-up to characterize the sensitization status in the Japanese population. Methods: The cross-sectional study was conducted for consecutive LTX recipients who underwent transplantation from January 2000 to January 2020 at Tohoku University Hospital (TUH). The serum from the recipients was screened for anti-HLA antibody with the panel-reactive assay (PRA) and the donor-specific antibodies (DSA). Results: Sensitization was reviewed in 93 LTX recipients, showing 23 positive (24.7%) and 70 negative (75.3%) PRA. More sensitized recipients were found in recent transplantations (60.9% (14/23), ≤5 years post LTX) than in older transplantations (17.4% (4/23), 5–10 years or 21.7% (5/23), ≥10 years post LTX) (p = 0.04). Even fewer recipients had DSA (5.4%, 5/93), among whom 4/5 (80%) were recently transplanted. Conclusion: The rate of PRA positive LTX recipients in our population was lower compared with those in previous reports from US and Europe. More sensitized LTRs were found in recent transplantations than the older cohort, and DSA was identified primarily in the recent recipients. Due to several limitations, it is still unclear whether the sensitization would be related the development of CLAD or survival, yet this study would be fundamental to the future anti-HLA body study in Japanese population. Keywords: Lung transplant, Panel-reactive assay (PRA), Donor-specific antibodies (DSA), Japan, Human leukocyte antigen (HLA), Chronic lung allograft dysfunction (CLAD)
* Correspondence: [email protected] † Sakiko Kumata and Takashi Hirama contributed equally to this work. 1 Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan 2 Division of Organ Transplantation, Tohoku University Hospital, 4-1 Seiryomachi, Sendai, Miyagi 980-8574, Japan Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material
Data Loading...
