The Functional Nucleus
This book gives an in-depth overview on nuclear structure and function. It clearly shows that the epigenome and the three-dimensional organization of the nucleus are not independent properties. The intimate relationship between the location and the e
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Functional Nucleus
The Functional Nucleus
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David P. Bazett-Jones • Graham Dellaire Editors
The Functional Nucleus
Editors David P. Bazett-Jones Genetics and Genome Biology The Hospital for Sick Children Toronto, Ontario Canada
Graham Dellaire Dalhousie University Halifax, Nova Scotia Canada
ISBN 978-3-319-38880-9 ISBN 978-3-319-38882-3 DOI 10.1007/978-3-319-38882-3
(eBook)
Library of Congress Control Number: 2016951228 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland
Contents
Part I
Nuclear Periphery
Human Diseases Related to Nuclear Envelope Proteins . . . . . . . . . . . . . Howard J. Worman Part II
3
Nuclear Bodies
The Nucleolus: Structure and Function . . . . . . . . . . . . . . . . . . . . . . . . . Marie-Line Dubois and Franc¸ois-Michel Boisvert
29
Pre-mRNA Splicing and Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Michael R. Ladomery and Sebastian Oltean
51
Acute Promyelocytic Leukaemia: Epigenetic Function of the PML-RARα Oncogene . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Julia P. Hofmann and Paolo Salomoni Part III
71
Chromosomes
Spatial Genome Organization and Disease . . . . . . . . . . . . . . . . . . . . . . . 101 Karen J. Meaburn, Bharat Burman, and Tom Misteli Telomeres and Chromosome Stability . . . . . . . . . . . . . . . . . . . . . . . . . . 127 Tsz Wai Chu and Chantal Autexier Part IV
Nuclear Domains and Development
Polycomb Bodies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 157 Vincenzo Pirrotta The Continuing Flight of Ikaros . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175 Karen E. Brown
v
vi
Part V
Contents
Nuclear Domains and Cell Stress
Senescence Associated Heterochromatic Fo
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