The Genetics of Type 2 Diabetes and Related Traits Biology, Physiolo
This book presents the state of the art of type 2 diabetes genetics, from the process of genetic discovery to its interpretation and clinical application, and illustrates a model for other complex human phenotypes.The first section explores genome-wide as
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The Genetics of Type 2 Diabetes and Related Traits Biology, Physiology and Translation
The Genetics of Type 2 Diabetes and Related Traits
ThiS is a FM Blank Page
Jose C. Florez Editor
The Genetics of Type 2 Diabetes and Related Traits Biology, Physiology and Translation
Editor Jose C. Florez Diabetes Unit Center for Human Genetic Research Massachusetts General Hospital Programs in Metabolism and Medical & Population Genetics Broad Institute Department of Medicine Harvard Medical School Boston Massachusetts USA
ISBN 978-3-319-01573-6 ISBN 978-3-319-01574-3 DOI 10.1007/978-3-319-01574-3
(eBook)
Library of Congress Control Number: 2015958349 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland
Preface
When Victor Neel termed type 2 diabetes (T2D) “the geneticist’s nightmare,” (Neel 1962) it was already evident that T2D harbored a familial component; yet its polygenic genetic architecture, the inherent limitations in the techniques available at the time, and the strong (and growing!) influence of environmental determinants made genetic discovery an arduous task. In the 50 years since then, the public health impact of T2D has only skyrocketed, fueled by the changes in modern lifestyle increasingly adopted by developing societies and the expansion of caloric superabundance. As a result, T2D and its complications represent one of the most serious challenges to public health in the twenty-first century. We live in the midst of a worldwide pandemic that threatens to undermine the significant gains we have made against cardiovascular disease over the last few decades. Despite its status as one of the oldest known endocrinopathies, the availability of a molecular therapy since 1920, and the existence of over a dozen drug classes approved for the management of the disease,
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