The Haskins pediatric atlas: a magnetic-resonance-imaging-based pediatric template and atlas
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ORIGINAL ARTICLE
The Haskins pediatric atlas: a magnetic-resonance-imaging-based pediatric template and atlas Peter J. Molfese 1,2 & Daniel Glen 3 & Laura Mesite 1 & Robert W. Cox 3 & Fumiko Hoeft 1,4 & Stephen J. Frost 1 & W. Einar Mencl 1 & Kenneth R. Pugh 1 & Peter A. Bandettini 2 Received: 21 February 2020 / Revised: 21 August 2020 / Accepted: 8 October 2020 # This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2020
Abstract Background Spatial normalization plays an essential role in multi-subject MRI and functional MRI (fMRI) experiments by facilitating a common space in which group analyses are performed. Although many prominent adult templates are available, their use for pediatric data is problematic. Generalized templates for pediatric populations are limited or constructed using older methods that result in less ideal normalization. Objective The Haskins pediatric templates and atlases aim to provide superior registration and more precise accuracy in labeling of anatomical and functional regions essential for all fMRI studies involving pediatric populations. Materials and methods The Haskins pediatric templates and atlases were generated with nonlinear methods using structural MRI from 72 children (age range 7–14 years, median 10 years), allowing for a detailed template with corresponding parcellations of labeled atlas regions. The accuracy of these templates and atlases was assessed using multiple metrics of deformation distance and overlap. Results When comparing the deformation distances from normalizing pediatric data between this template and both the adult templates and other pediatric templates, we found significantly less deformation distance for the Haskins pediatric template (P
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