The Heritability of Type D Personality by an Extended Twin-Pedigree Analysis in the Netherlands Twin Register
- PDF / 643,872 Bytes
- 11 Pages / 595.276 x 790.866 pts Page_size
- 20 Downloads / 254 Views
ORIGINAL RESEARCH
The Heritability of Type D Personality by an Extended Twin‑Pedigree Analysis in the Netherlands Twin Register Ruifang Li‑Gao1,2,3 · Dorret I. Boomsma2 · Eco J. C. de Geus2 · Johan Denollet1 · Nina Kupper1 Received: 4 December 2019 / Accepted: 21 September 2020 © The Author(s) 2020
Abstract Type D (Distressed) personality combines negative affectivity (NA) and social inhibition (SI) and is associated with an increased risk of cardiovascular disease. We aimed to (1) validate a new proxy based on the Achenbach System of Empirically Based Assessment (ASEBA) for Type D personality and its NA and SI subcomponents and (2) estimate the heritability of the Type D proxy in an extended twin-pedigree design in the Netherlands Twin Register (NTR). Proxies for the dichotomous Type D classification, and continuous NA, SI, and NAxSI (the continuous measure of Type D) scales were created based on 12 ASEBA items for 30,433 NTR participants (16,449 twins and 13,984 relatives from 11,106 pedigrees) and sources of variation were analyzed in the ‘Mendel’ software package. We estimated additive and non-additive genetic variance components, shared household and unique environmental variance components and ran bivariate models to estimate the genetic and non-genetic covariance between NA and SI. The Type D proxy showed good reliability and construct validity. The best fitting genetic model included additive and non-additive genetic effects with broad-sense heritabilities for NA, SI and NAxSI estimated at 49%, 50% and 49%, respectively. Household effects showed small contributions (4–9%) to the total phenotypic variation. The genetic correlation between NA and SI was .66 (reflecting both additive and non-additive genetic components). Thus, Type D personality and its NA and SI subcomponents are heritable, with a shared genetic basis for the two subcomponents. Keywords Pedigree analysis · Heritability · Type D personality · Negative affectivity · Social inhibition · Genetic nonadditivity · Shared household effect · Extended twin-family design · Netherlands Twin Register
Introduction Edited by Valerie Knopik. Prof. Dr. Johan Denollet passed away on October 26, 2019. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10519-020-10023-x) contains supplementary material, which is available to authorized users. * Ruifang Li‑Gao [email protected] 1
CoRPS Center of Research On Psychology in Somatic Diseases, Tilburg University, Tilburg, The Netherlands
2
Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
3
Dept of Medical and Clinical Psychology, Center of Research On Psychology in Somatic Diseases (CoRPS), Tilburg University, P. O. Box 90153, 5000 LE Tilburg, The Netherlands
Type D or Distressed personality is an established risk factor for the development and poor prognosis of coronary artery disease (Beutel et al. 2012; Denollet et al. 2013; Grande et al. 2012; Kupper and Denollet 2018; Wang et al. 2016). Type D personality also has
Data Loading...
